The role of progesterone receptor membrane component (PGRMC) in the endometrium

Dora Maria Velázquez Hernández, Velázquez Hernández DM, Edgar Ricardo Vázquez-Martínez, Camacho-Arroyo I, Ignacio Camacho-Arroyo, Ignacio Camacho‐Arroyo
Steroids · 2022 · vol. 184 , pp. 109040 · doi:10.1016/j.steroids.2022.109040 · PMID:35526781 · W4229027324
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This paper investigates the function of progesterone receptor membrane component (PGRMC) within the endometrium, exploring its involvement in endometrial processes.

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Abstract

PGRMC is a non-classical receptor that mediates the non-genomic responses to progesterone and is distributed in different subcellular compartments. PGRMC belongs to the membrane-associated progesterone receptor (MAPR) family. Two PGRMC subtypes (PGRMC1 and PGRMC2) have been characterized, and both are expressed in the human endometrium. PGRMC expression is differentially regulated during the menstrual cycle in the human endometrium. Although PGRMC1 is predominantly expressed in the proliferative phase and PGRMC2 in the secretory phase, this expression changes in pathologies such as endometriosis, in which PGRMC2 expression considerably decreases, promoting progesterone resistance. In endometrial cancer, PGRMC1 is overexpressed, its activation induces tumors growth, and confers chemoresistance in the presence of progesterone. Thus, PGRMCs play a key role in progesterone actions in the endometrium.

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MeSH descriptors

Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium

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