Association of rs1800790 in FGB and Endometrium in Iranian Women

Pooria Omidi, Mehrdad Hashemi, Ahmad Ebrahimi
In: Indian Journal of Science and Technology · 2016 · vol. 9(7) · doi:10.17485/ijst/2016/v9i7/87732 · W2293890481
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This case-control study in Iranian women found a significant association between FGB gene polymorphism rs1800790 genotypes and an increased risk of endometriosis.

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Abstract

Background/Objectives: Endometriosis is a disease with the growth of endometrium-like tissue in aberrant locations outside of the uterine.Variants of a number of genes have been associated to endometriosis; however, the contributions of these genetic variants in different ethnic groups are not similar. Methods/Statistical Analysis: Our study isAssociation of rs1800790 in FGB and endometrium in Iranian women. The case–control study included 100 affected patients and 100 controls. The genetic variants on FGB gene was genotyped using Tetra Amplification Refractory Mutation SystemPolymerase Chain Reaction (Tetra-ARMS-PCR).Findings: Association of risk allele with endometriosis was examined using SPSS software. Results showed that FGB gene polymorphism genotype frequencies were compared in the patients and control. Frequency of AA, AG and GG genotypes of the gene polymorphism fibrinogen beta polypeptide chain were28, 48and 24% in patients respectively, and66, 31and 3% in control group respectively. Results showed that relation between patients and control group is significant (P=4.619e-11).Applications/Improvements: This study showed that there was meaningful relationship between FGB gene polymorphism and increased risk of endometriosis in women studied. Keywords: Endometriosis, FGB Gene, rs1800790, Women
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endometriosis

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