Association of rs1800790 in FGB and Endometrium in Iranian Women

Pooria Omidi, Mehrdad Hashemi, Ahmad Ebrahimi
In: Indian Journal of Science and Technology · 2016 · vol. 9(7) · doi:10.17485/ijst/2016/v9i7/87732 · W2293890481
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This case-control study in Iranian women found a significant association between FGB gene polymorphism rs1800790 genotypes and an increased risk of endometriosis.

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The provided text contains only metadata, journal navigation menus, and publication policies for the Indian Journal of Science and Technology rather than the actual content of the research article. Consequently, it is impossible to determine what was studied, the population or methods used, or any key findings related to the rs1800790 polymorphism in the FGB gene. The title suggests a focus on genetic associations within Iranian women, but no abstract or results are present in the input data to verify this or describe the study's outcomes. Relevance to endometriosis: The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background/Objectives: Endometriosis is a disease with the growth of endometrium-like tissue in aberrant locations outside of the uterine.Variants of a number of genes have been associated to endometriosis; however, the contributions of these genetic variants in different ethnic groups are not similar. Methods/Statistical Analysis: Our study isAssociation of rs1800790 in FGB and endometrium in Iranian women. The case–control study included 100 affected patients and 100 controls. The genetic variants on FGB gene was genotyped using Tetra Amplification Refractory Mutation SystemPolymerase Chain Reaction (Tetra-ARMS-PCR).Findings: Association of risk allele with endometriosis was examined using SPSS software. Results showed that FGB gene polymorphism genotype frequencies were compared in the patients and control. Frequency of AA, AG and GG genotypes of the gene polymorphism fibrinogen beta polypeptide chain were28, 48and 24% in patients respectively, and66, 31and 3% in control group respectively. Results showed that relation between patients and control group is significant (P=4.619e-11).Applications/Improvements: This study showed that there was meaningful relationship between FGB gene polymorphism and increased risk of endometriosis in women studied. Keywords: Endometriosis, FGB Gene, rs1800790, Women
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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

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