Serum levels of estradiol and follicle stimulating hormone,and vasomotor symptoms in Thai women receivingGnRH analogue before laparoscopic enucleationof endometriotic cysts

Suvit Bunyavejchevin
In: Chulalongkorn Medical Journal · 2012 · vol. 56(5) , pp. 557–567 · doi:10.58837/chula.cmj.56.5.5 · W4391196681
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study found that leuprolide acetate suppressed estradiol and FSH levels in Thai women with endometriotic cysts, leading to amenorrhea and increased vasomotor symptoms in some.

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This study investigated serum estradiol (E2) and follicle-stimulating hormone (FSH) levels and vasomotor symptoms in 60 Thai women (ages 15–44) with endometriotic cysts treated with leuprolide acetate 3.75 mg intramuscularly every month for 3 months prior to laparoscopic enucleation. Serum E2 and FSH were measured at baseline and at 1, 2, and 3 months, and vasomotor symptoms were assessed using the Thai version of the Greene climacteric score; the main limitation noted from the abstract is that follow-up was limited to the 3-month treatment window. E2 levels decreased significantly by 1 month, and FSH decreased significantly at 1–3 months; by 3 months, most women had amenorrhea (93.3%) with relatively low use of sedative medication (8.3%) despite higher mean vasomotor symptom scores at 2 and 3 months. This paper is centrally about endometriosis — it studies GnRH analogue–induced suppression of ovarian hormones and resulting vasomotor symptoms in women with endometriotic cysts undergoing preoperative treatment.

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Abstract

Background : GnRH analogue can suppress serum estradiol (E2) and follicle stimulating hormone (FSH) to menopause level before laparoscopic enucleation of endometriotic cysts. Objective : To study the levels of E2 and FSH, and vasomotor symptoms after GnRH analogue treatment in Thai women with endometriotic cysts. Materials and Methods : During January, 2006 - December, 2007. Sixty women diagnosed as having endometriotic cysts, aged 15 - 44 years, were recruited into the study. Leuprolide acetate 3.75 mg was given intramuscularly at one month interval for 3 months. Serum levels of E2 and FSH were tested at 0, 1, 2 and 3 months after GnRH analogue treatments. Thai version of Greene climacteric score was recorded at 0, 1, 2 and 3 months. Results : The median (25th percentile, 75th percentile) of serum E2 level decreased significantly from the baseline (0 months: 232.3 (82.0,446.2) pmol/L vs. 1 months : 18.4(0,44.9) pmol/L, 2 months: 31.7(0,58.6) pmol/L, 3 months: 0(0,54.2) pmol/L). The median (25th percentile, 75th percentile) of serum FSH level decreased significantly from the baseline at 1,2 and 3 months. (0 months: 4.8(3.1,7.0) IU/L vs. 1 months: 2.2(1.3,3.5) IU/L, 2 months 2.8 (1.8,5.2) ,3 months 3.0(2.8,4.9) IU/L). Only 8.3% of women required sedative medication for vasomotor symptoms relief. The mean vasomotor symptoms scores were significantly higher than the baseline at 2 and 3 months period (0 months: 14.5 vs. 2 months: 20.0 and 3 months: 20.2). Most women had amenorrhea at 3 months period (93.3%). Conclusion : Leuprolide acetate can suppress ovarian function after the first month of injection. Most women can stand the vasomotor symptoms. Amenorrhea was the most common menstrual patterns at 3 months after injection.
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Abstract Background : GnRH analogue can suppress serum estradiol (E2) and follicle stimulating hormone (FSH) to menopause level before laparoscopic enucleation of endometriotic cysts. Objective : To study the levels of E2 and FSH, and vasomotor symptoms after GnRH analogue treatment in Thai women with endometriotic cysts. Materials and Methods : During January, 2006 - December, 2007. Sixty women diagnosed as having endometriotic cysts, aged 15 - 44 years, were recruited into the study. Leuprolide acetate 3.75 mg was given intramuscularly at one month interval for 3 months. Serum levels of E2 and FSH were tested at 0, 1, 2 and 3 months after GnRH analogue treatments. Thai version of Greene climacteric score was recorded at 0, 1, 2 and 3 months. Results : The median (25th percentile, 75th percentile) of serum E2 level decreased significantly from the baseline (0 months: 232.3 (82.0,446.2) pmol/L vs. 1 months : 18.4(0,44.9) pmol/L, 2 months: 31.7(0,58.6) pmol/L, 3 months: 0(0,54.2) pmol/L). The median (25th percentile, 75th percentile) of serum FSH level decreased significantly from the baseline at 1,2 and 3 months. (0 months: 4.8(3.1,7.0) IU/L vs. 1 months: 2.2(1.3,3.5) IU/L, 2 months 2.8 (1.8,5.2) ,3 months 3.0(2.8,4.9) IU/L). Only 8.3% of women required sedative medication for vasomotor symptoms relief. The mean vasomotor symptoms scores were significantly higher than the baseline at 2 and 3 months period (0 months: 14.5 vs. 2 months: 20.0 and 3 months: 20.2). Most women had amenorrhea at 3 months period (93.3%). Conclusion : Leuprolide acetate can suppress ovarian function after the first month of injection. Most women can stand the vasomotor symptoms. Amenorrhea was the most common menstrual patterns at 3 months after injection. DOI 10.58837/CHULA.CMJ.56.5.5 First Page 557 Last Page 567 Recommended Citation Bunyavejchevin, S and Wisawasukmongchol, W. (2012) "Serum levels of estradiol and follicle stimulating hormone, and vasomotor symptoms in Thai women receiving GnRH analogue before laparoscopic enucleation of endometriotic cysts," Chulalongkorn Medical Journal: Vol. 56: Iss. 5, Article 5. DOI: https://doi.org/10.58837/CHULA.CMJ.56.5.5 Available at: https://digital.car.chula.ac.th/clmjournal/vol56/iss5/5

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