Effect of endometrioma cyst fluid exposure on peritoneal adhesion formation in a rabbit model

Laura Smith, Laura Proud Smith, Smith LP, Williams CD, Christopher D. Williams, Joseph O'Brien Doyle, Joseph Doyle, Doyle JO, Closshey WB, Wendy B. Closshey, Brix WK, William K. Brix, Lisa M. Pastore
Fertility and sterility · 2007 · vol. 87(5) , pp. 1173–1179 · doi:10.1016/j.fertnstert.2006.08.104 · PMID:17258215 · W2167282114
RCT OA: bronze CC0 ⤵ 10 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study investigated whether endometrioma cyst fluid promotes peritoneal adhesion formation in a rabbit model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine whether copious lavage and suction of human endometrioma fluid placed in the peritoneal cavity of rabbits reduces adhesion formation compared to no lavage. DESIGN: Prospective, randomized, blinded study. SETTING: Academic research environment. ANIMAL(S): Twenty-four female New Zealand white rabbits. INTERVENTION(S): Rabbits randomized into three groups: [1] laparoscopy with instillation of human endometrioma material, no lavage; [2] laparoscopy with instillation of human endometrioma material, followed by clearance of all visible endometrioma fluid by saline lavage and suction; [3] laparoscopy alone. MAIN OUTCOME MEASURE(S): Six weeks after laparoscopy, adhesions scored by laparotomy using standard visual assessment scoring system and histologic microscopic evaluation. Data evaluated using Kruskal-Wallis and median nonparametric tests. RESULT(S): For groups 1, 2, and 3, respectively, mean total clinical adhesion scores were 0.67 (95% confidence interval [CI] -0.87, 2.2), 3.67 (95% CI 1.27, 6.07), and 0 (95% CI 0, 0). Group 2 had statistically significantly higher mean adhesion scores compared to group 1. Histologic adhesion scores followed the trend of clinical adhesion scores. CONCLUSION(S): In this rabbit model, human endometrioma fluid exposure in the peritoneal cavity is not associated with adhesion formation. Instillation of endometrioma fluid followed by copious saline lavage is strongly associated with adhesion formation.

My notes (saved in your browser only)

Condition tags

endometriosisendometrioma

MeSH descriptors

Cyst Fluid Cyst Fluid Endometriosis Peritoneal Diseases Animals Animals Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Female Humans Humans Peritoneal Cavity Peritoneal Cavity Peritoneal Cavity Peritoneal Diseases Peritoneal Diseases

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (11)

Source provenance

europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
openalex
last seen: 2026-05-11T05:40:41.230350+00:00
pubmed
last seen: 2026-10-08T21:04:12.251519+00:00
License: CC0 · commercial use OK