Effect of endometrioma cyst fluid exposure on peritoneal adhesion formation in a rabbit model

Laura Smith, Laura Proud Smith, Smith LP, Williams CD, Christopher D. Williams, Joseph O'Brien Doyle, Joseph Doyle, Doyle JO, Closshey WB, Wendy B. Closshey, Brix WK, William K. Brix, Lisa M. Pastore
Fertility and sterility · 2007 · vol. 87(5) , pp. 1173–1179 · doi:10.1016/j.fertnstert.2006.08.104 · PMID:17258215 · W2167282114
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This study investigated whether endometrioma cyst fluid promotes peritoneal adhesion formation in a rabbit model.

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Abstract

ObjectiveTo determine whether copious lavage and suction of human endometrioma fluid placed in the peritoneal cavity of rabbits reduces adhesion formation compared to no lavage.DesignProspective, randomized, blinded study.SettingAcademic research environment.Animal(s)Twenty-four female New Zealand white rabbits.Intervention(s)Rabbits randomized into three groups: [1] laparoscopy with instillation of human endometrioma material, no lavage; [2] laparoscopy with instillation of human endometrioma material, followed by clearance of all visible endometrioma fluid by saline lavage and suction; [3] laparoscopy alone.Main outcome measure(s)Six weeks after laparoscopy, adhesions scored by laparotomy using standard visual assessment scoring system and histologic microscopic evaluation. Data evaluated using Kruskal-Wallis and median nonparametric tests.Result(s)For groups 1, 2, and 3, respectively, mean total clinical adhesion scores were 0.67 (95% confidence interval [CI] -0.87, 2.2), 3.67 (95% CI 1.27, 6.07), and 0 (95% CI 0, 0). Group 2 had statistically significantly higher mean adhesion scores compared to group 1. Histologic adhesion scores followed the trend of clinical adhesion scores.Conclusion(s)In this rabbit model, human endometrioma fluid exposure in the peritoneal cavity is not associated with adhesion formation. Instillation of endometrioma fluid followed by copious saline lavage is strongly associated with adhesion formation.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cyst Fluid Endometriosis Peritoneal Diseases Animals Disease Models, Animal Endometriosis Endometriosis Female Humans Peritoneal Cavity Peritoneal Cavity Peritoneal Diseases Peritoneal Diseases Peritoneal Lavage Peritoneal Lavage Prospective Studies Rabbits Tissue Adhesions Tissue Adhesions Tissue Adhesions

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References (22)

Cited by (10)

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