Clear Cell Carcinoma of the Ovary

Keiichi Fujiwara, Katsutoshi Oda, Masashi Takano, Noriomi Matsumura
In: Textbook of Uncommon Cancer · 2017 · pp. 550–556 · doi:10.1002/9781119196235.ch37 · W4251355657
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

Clear cell ovarian carcinoma, characterized by ARID1A/PIK3CA mutations and prevalent in Japan, may arise from endometriosis and exhibits chemoresistance, necessitating novel targeted therapies.

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Abstract

Clear cell carcinoma of the ovary is a distinct histological subtype of epithelial ovarian cancer characterized by mutations in ARID1A and PIK3CA. These malignancies account for a larger proportion of cancers in Japan than in other areas of the world, and they may be related to precancerous lesions in atypical endometriosis and adenofibroma of the ovary. While the initial treatment strategy parallels that for the more common high-grade serous epithelial ovarian cancers, these tumors may be relatively more chemoresistant, so investigation centers on novel strategies incorporating targeted agents for advanced or relapsed disease.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (62)

Source provenance

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