A comparative assessment of efficacy for pain relief and quality of life between dienogest and combined oral contraceptive pills in endometriosis patients in Eastern India

Priyanka Kumari, Rathindra Nath Ray, Sandip Sarkar, S. G. Dastidar, Yogesh Munde
In: MGM Journal of Medical Sciences · 2025 · vol. 12(2) , pp. 322–330 · doi:10.4103/mgmj.mgmj_113_25 · W4411930400
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Dienogest demonstrated superior pelvic pain reduction compared to combined oral contraceptive pills in Eastern Indian endometriosis patients after six months, with both treatments showing slight quality of life improvements.

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Abstract

Abstract Background: This study aimed to compare the effectiveness of dienogest (DNG) and combined oral contraceptive (COC) pills in alleviating pain among patients with endometriosis in Eastern India. Materials and Methods: A prospective, hospital-based, observational comparative study was conducted at R. G. Kar Medical College and Hospital in Kolkata, India, from March 2021 to August 2022. The study included two groups: Group A (dienogest 2 mg/day, n = 115) and Group B (combined oral contraceptive pills, Mala-N, n = 115). Pain levels were assessed using the Visual Analog Scale (VAS), and the quality of life (QoL) was evaluated with the Endometriosis Health Profile Questionnaire (EHP-5 PRO) after 3 and 6 months of treatment. Results: The mean age ± standard deviation was 32.57 ± 8.02 years in Group A and 32.89 ± 7.92 years in Group B. After 6 months, Group A showed a significant reduction in pelvic pain ( P = 0.001), whereas Group B did not experience a significant improvement ( P = 0.55). A significant difference in pain reduction was observed between the two groups after 6 months ( P = 0.0001). Both treatments resulted in slight improvements in the quality of life, but the difference between the groups was not statistically significant. Conclusion: Both dienogest and COC pills may assist in managing endometriosis-related pain and enhancing the quality of life, with dienogest showing superior pain relief. These medications appear to be safe and effective options for managing endometriosis.

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Outcome instruments

EHP-30 VAS-pain MUSA

Condition tags

endometriosis

Citation neighborhood

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References (29)

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