Nafarelin in the treatment of pelvic pain caused by endometriosis
RCT
OA: closed
CC0
⤵ 22 in-corpus citations
AI-generated summary
This study investigated the efficacy of nafarelin acetate in alleviating pelvic pain associated with endometriosis.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
As part of a large, multicenter trial, 82 patients with endometriosis were randomized to 6 months of treatment with either nafarelin or danazol. Among 73 patients who had subjective symptoms (dysmenorrhea, dyspareunia, or pelvic pain) at baseline, 94% of patients treated with nafarelin and 91% of those treated with danazol had improvement. Resolution of physical findings also was observed in similar percentages of patients in each treatment group. Long-term studies are needed to determine whether these two agents are associated with different cure rates or times to recurrence of disease.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (1)
Cited by (22)
- A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action 2024
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Analogs of Luteinizing Hormone-Releasing Hormone in the Treatment of Endometriosis 2015
- Systematic review of endometriosis pain assessment: how to choose a scale? 2014
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Ovulation suppression for endometriosis for women with subfertility 2007
- GnRH analogs: options for endometriosis-associated pain treatment 2006
- GnRH agonist and antagonist: Options for endometriosis pain treatment 2006
- Endometriosis is a Surgical Disease 2003
- Adolescent endometriosis: diagnosis and treatment approaches 2003
- Ovulation suppression for endometriosis 2003
- Medical and surgical therapies for pain associated with endometriosis 2001
- Endometriosis 2000
- WITHDRAWN: Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Endometriosis and Pelvic Pain 1998
- Biases in the endometriosis literature. Illustrated by 20 years of endometriosis research in Leuven 1998
- Pain recurrence: a quality of life issue in endometriosis 1995
- Pathogenesis of Pelvic Pain in Endometriosis 1995
- Can hormone replacement therapy be used during medical therapy of endometriosis? 1994
- Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex hormone-related conditions 1991
- Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions 1990
Source provenance
- europepmc
- last seen: 2026-10-16T06:09:50.462052+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:08:38.374512+00:00
- unpaywall
- last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0
· commercial use OK