Nafarelin in the treatment of pelvic pain caused by endometriosis
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This study investigated the efficacy of nafarelin acetate in alleviating pelvic pain associated with endometriosis.
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Abstract
As part of a large, multicenter trial, 82 patients with endometriosis were randomized to 6 months of treatment with either nafarelin or danazol. Among 73 patients who had subjective symptoms (dysmenorrhea, dyspareunia, or pelvic pain) at baseline, 94% of patients treated with nafarelin and 91% of those treated with danazol had improvement. Resolution of physical findings also was observed in similar percentages of patients in each treatment group. Long-term studies are needed to determine whether these two agents are associated with different cure rates or times to recurrence of disease.
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Cited by (22)
- A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action 2024
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Analogs of Luteinizing Hormone-Releasing Hormone in the Treatment of Endometriosis 2015
- Systematic review of endometriosis pain assessment: how to choose a scale? 2014
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Ovulation suppression for endometriosis for women with subfertility 2007
- GnRH analogs: Options for endometriosis-associated pain treatment 2006
- GnRH agonist and antagonist: Options for endometriosis pain treatment 2006
- Endometriosis is a Surgical Disease 2003
- Adolescent Endometriosis 2003
- Ovulation suppression for endometriosis 2003
- Medical and Surgical Therapies for Pain Associated with Endometriosis 2001
- Endometriosis 2000
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Endometriosis and Pelvic Pain 1998
- Biases in the endometriosis literature 1998
- Pain recurrence: A quality of life issue in endometriosis 1995
- Pathogenesis of Pelvic Pain in Endometriosis 1995
- Can hormone replacement therapy be used during medical therapy of endometriosis? 1994
- Goserelin 1991
- Nafarelin 1990
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