[Expression of hypoxia-inducible factor-1alpha in endometriosis].

Xu Ren, Ren X, Yuanli He, He YL, Yuan-li He, Shi-lei Pan, Pan SL, Dong-Xian Peng, Peng DX
Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2007 · vol. 27(4) , pp. 538–40 · PMID:17545054 · W249820573
article OA: closed CC0 ⤵ 5 in-corpus citations
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Hypoxia-inducible factor-1alpha expression was significantly increased in ectopic endometrium compared to normal endometrium, suggesting a role in endometriosis pathogenesis.

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Abstract

OBJECTIVE: To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis. METHODS: Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically. RESULTS: The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium. CONCLUSION: HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hypoxia-Inducible Factor 1, alpha Subunit Adult Endometriosis Endometrium Female Humans Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Menstrual Cycle Menstrual Cycle

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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europepmc
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License: CC0 · commercial use OK