Expansion of monocytic myeloid-derived suppressor cells in endometriosis patients: A pilot study

Haiwen Chen, Chen H, Shuang Qin, Qin S, Aihua Lei, Lei A, Xing Li, Gao Q, Qi Gao, Jingyin Dong, Dong J, Xiao Q, Qing Xiao, Jie Zhou, Zhou J
International Immunopharmacology · 2017 · vol. 47 , pp. 150–158 · doi:10.1016/j.intimp.2017.03.026 · PMID:28407569 · W2605844998
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This pilot study investigated and found an expansion of monocytic myeloid-derived suppressor cells in patients diagnosed with endometriosis.

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Abstract

Endometriosis is a chronic inflammation disease and is closely associated with immune dysregulation. Myeloid-derived suppressor cells (MDSCs) are a negative regulator of the immune system. The aim of this study was to evaluate the possible role of MDSCs in endometriosis patients. We collected the peripheral blood and peritoneal fluid from endometriosis patients and controls and analyzed M-MDSCs level using specific monoclonal antibodies recognizing HLA-DR, CD33, CD11b, CD14 markers by flow cytometry. We found that there existed abnormal expansion of monocytic MDSCs (M-MDSCs) (HLA-DR-/lowCD33+CD11b+ CD14+) in peripheral blood and peritoneal fluid of patients with endometriosis. Functional studies revealed that M-MDSCs from endometriosis patients significantly suppressed T-cell responses and produced high level of reactive oxygen species (ROS). The elevation of M-MDSCs from endometriosis patients may contribute to the disease progression.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Monocytes Myeloid-Derived Suppressor Cells T-Lymphocytes Adolescent Adult CD11b Antigen CD11b Antigen Cell Proliferation Cells, Cultured Coculture Techniques Disease Progression Endometriosis Female HLA-DR Antigens HLA-DR Antigens Humans Immune Tolerance Lipopolysaccharide Receptors Lipopolysaccharide Receptors

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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