Endometriosis: A parametric analysis of a phenomenological-based endometrial model

Carolina Ramírez-Mazo, Laura Lema-Pérez, Lina Gomez Echavarria
In: 2021 IEEE 5th Colombian Conference on Automatic Control (CCAC) · 2021 · vol. 53 , pp. 110–115 · doi:10.1109/ccac51819.2021.9633321 · W4200076733
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This paper parametrically analyzes a phenomenological endometrial model, finding that an imbalance between estrogen and progesterone effects can lead to endometrial overgrowth, potentially explaining endometriosis dynamics.

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Abstract

This article presents the parametric analysis of two coupled models that describe sexual hormonal dynamics and endometrium growth in the menstrual cycle. The endometrial model uses the Monod equation as a constitutive equation in the mass balance of the proliferative and secretory cells. The parameters kpro and ksec in Monod equation can be interpreted as estrogen and progesterone effect, respectively, on the maximum growth rate of the endometrial tissue. These parameters are modified to investigate their impact on the dynamic behavior of endometrial volume. An imbalance between kpro and ksec, can generate an overgrowth of the endometrium, similar to the devolopment of endometriosis and therefore, an imbalance between the levels of estrogen and progesterone -an unopposed estrogen condition-becomes the scenario enhancing the pathology, rather than an isolated estrogen effect. Analysis of the model gives a possible explanation of the dynamics of endometriosis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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