Concurrent Terminal Ileocaecal Crohn's Disease and Terminal Ileal Endometriosis: Multimodal Assessment with CT, MRI, and PET/CT Imaging

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This paper discusses concurrent terminal ileocaecal Crohn's disease and terminal ileal endometriosis, noting that endometriosis can mimic Crohn's disease in women of childbearing age.

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This paper describes a case report of concurrent terminal ileocecal Crohn’s disease and terminal ileal endometriosis, assessed using multimodal imaging including CT, MRI, and PET/CT to evaluate and characterize the overlapping presentation in a woman of childbearing age. It is framed against the clinical challenge that intestinal endometriosis can mimic Crohn’s disease in the terminal ileum, and that inflammation patterns may be difficult to distinguish when symptoms are mild and rely on disease inflammatory activity. A key limitation is that, as presented, the work centers on imaging interpretation in a single case rather than providing generalizable diagnostic performance estimates. This paper is centrally about endometriosis — it specifically presents terminal ileal endometriosis occurring concurrently with terminal ileocecal Crohn’s disease and addresses how multimodal imaging supports assessment of the overlap.

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Introduction

Crohnʼs disease (CD), a kind of chronic inflammatory bowel illness, commonly affects the terminal ileum and coecal area. Clinical signs are frequently mild and rely on the disease's inflammatory activity. In women of childbearing age, florid intestinal endometriosis can mimic CD. Furthermore, modern pathophysiological ideas identify intestinal endometriosis as a potential founder lesion for successive CD creation. When the terminal ileum is afflicted in a woman of childbearing age, endometriosis should be considered [1]. Publication History Received: 11 June 2025 Accepted after revision: 19 July 2025 Article published online: 30 July 2025 © 2025. Thieme. All rights reserved. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany -

References

- 1 Kaemmerer E, Westerkamp M, Kasperk R. et al. Coincidence of active Crohn's disease and florid endometriosis in the terminal ileum: a case report. World J Gastroenterol 2013; 19 (27) 4413-4417 - 2 Okeke TC, Ikeako LC, Ezenyeaku CC. Endometriosis. Niger J Med 2011; 20 (02) 191-199 - 3 Bergqvist A. Different types of extragenital endometriosis: a review. Gynecol Endocrinol 1993; 7 (03) 207-221 - 4 Chiaffarino F, Cipriani S, Ricci E. et al. Endometriosis and inflammatory bowel disease: A systematic review of the literature. Eur J Obstet Gynecol Reprod Biol 2020; 252: 246-251 - 5 Olive DL, Schwartz LB. Endometriosis. N Engl J Med 1993; 328 (24) 1759-1769 - 6 Minocha A, Davis MS, Wright RA. Small bowel endometriosis masquerading as regional enteritis. Dig Dis Sci 1994; 39 (05) 1126-1133 - 7 Boulton R, Chawla MH, Poole S. et al. Ileal endometriosis masquerading as Crohnʼs ileitis. J Clin Gastroenterol 1997; 25 (01) 338-342 - 8 Cappell MS, Friedman D, Mikhail N. Endometriosis of the terminal ileum simulating the clinical, roentgenographic and surgical findings in Crohn's disease. Am J Gastroenterol 1991; 86 (08) 1057-1062 - 9 Gómez-Rubio M, Fernández R, de Cuenca B. et al. Intestinal endometriosis as a cause of chronic abdominal pain leading to intestinal obstruction. Am J Gastroenterol 1997; 92 (03) 525-526 - 10 Craninx M, D'Haens G, Cokelaere K. et al. Crohnʼs disease and intestinal endometriosis: an intriguing co-existence. Eur J Gastroenterol Hepatol 2000; 12 (02) 217-221 - 11 Lee KK, Jharap B, Maser EA. et al. Impact of concomitant endometriosis on phenotype and natural history of inflammatory bowel disease. Inflamm Bowel Dis 2016; 22 (01) 159-163

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