Danazol induced pancreatitis and hepatitis

Xavier Chevalier, H Awada, A Baetz, B Amor
In: Clinical Rheumatology · 1990 · vol. 9(2) , pp. 239–241 · doi:10.1007/bf02031976 · PMID:2390854 · W2087773871
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A patient treated with 400 mg/day of danazol developed mild pancreatitis and hepatitis, both attributed to the drug.

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This paper reports a case in which a patient taking danazol 400 mg/day for systemic lupus erythematosus developed mild pancreatitis accompanied by hepatitis, which the authors attribute to danazol. The study is not an experimental or population-based analysis, but a single-patient clinical observation with limited generalizability. The key finding is that danazol can be associated with simultaneous pancreatic and liver injury manifesting as mild pancreatitis and hepatitis. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Summary Danazol, a C17 alkylated anabolic steroid, has been tried as a hormonomodulator in the management of systemic lupus erythematosus. We report the case of a patient receiving 400 mg of danazol per day who developed mild pancreatitis associated with hepatitis, both induced by danazol. Similar content being viewed by others References Madanes, A.E., Farber, M. Danazol. Ann Intern Med 1982, 96, 625–30. Spooner, S.B. Classification of side-effects of danazol therapy. J Intern Med Res 1977, 5 (suppl. 3), 15. Dougados, M., Job-Deslandre, C., Amor, B., Menkes, C.J. Danazol therapy in systemic lupus erythematosus: a one-year prospective controlled trial on 40 female patients. J Clin Trials 1987, 24, 19–20. Agnello, V., Gell, S., Pariser, K. Preliminary observation on danazol therapy of systemic lupus disseminated effects on DNA antibodies, thrombocytopenia and complement. J Rheumatol 1983, 10, 682–7. Pearson, K., Zimmermann, S.H. Danazol and liver damage. Lancet 1980, 2, 645–6. Cicardi, M., Bergamaschini, P., Tucci, A. Agostini, A., Tornaghi, C. Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives. Allergy Clin Immunol, 1972, 3, 294–7. Stricker, B.H., Sparstesa, P. Drug-induced hepatotoxic injury. Amsterdam: Elsevier Published Sciences, 1985. Rettenmaier, H., Pancreas. Eds: De Viegler, M., Holmes, J.H., Dratochwill, A., Kazner, E., Kraus, R., Kossof, G., Poulol, J., Strandness, D.E. In: Handbook of Clinical Ultrasound. New-York: John Willey and Sons, 1978, 335–43. Mallory, A., Kern, F. Drug-induced pancreatitis: a critical review. Gastroenterology 1980, 78, 813–20. Reynolds, J.C., Inman, R., Kimberg, R.P., Chuong, S.H., Kovacs, J.E., Walsh, M.B. Acute pancreatitis in systemic lupus disseminated. Report of twenty cases and a review of the literature. Medicine (Baltimore) 1982, 61, 25–33. Author information Authors and Affiliations Rights and permissions About this article Cite this article Chevalier, X., Awada, H., Baetz, A. et al. Danazol induced pancreatitis and hepatitis. Clin Rheumatol 9, 239–241 (1990). https://doi.org/10.1007/BF02031976 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF02031976

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