{"paper_id":"881fe4ff-d4da-4854-99f6-c0f0317096d8","body_text":"Summary\nDanazol, a C17 alkylated anabolic steroid, has been tried as a hormonomodulator in the management of systemic lupus erythematosus. We report the case of a patient receiving 400 mg of danazol per day who developed mild pancreatitis associated with hepatitis, both induced by danazol.\nSimilar content being viewed by others\nReferences\nMadanes, A.E., Farber, M. Danazol. Ann Intern Med 1982, 96, 625–30.\nSpooner, S.B. Classification of side-effects of danazol therapy. J Intern Med Res 1977, 5 (suppl. 3), 15.\nDougados, M., Job-Deslandre, C., Amor, B., Menkes, C.J. Danazol therapy in systemic lupus erythematosus: a one-year prospective controlled trial on 40 female patients. J Clin Trials 1987, 24, 19–20.\nAgnello, V., Gell, S., Pariser, K. Preliminary observation on danazol therapy of systemic lupus disseminated effects on DNA antibodies, thrombocytopenia and complement. J Rheumatol 1983, 10, 682–7.\nPearson, K., Zimmermann, S.H. Danazol and liver damage. Lancet 1980, 2, 645–6.\nCicardi, M., Bergamaschini, P., Tucci, A. Agostini, A., Tornaghi, C. Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives. Allergy Clin Immunol, 1972, 3, 294–7.\nStricker, B.H., Sparstesa, P. Drug-induced hepatotoxic injury. Amsterdam: Elsevier Published Sciences, 1985.\nRettenmaier, H., Pancreas. Eds: De Viegler, M., Holmes, J.H., Dratochwill, A., Kazner, E., Kraus, R., Kossof, G., Poulol, J., Strandness, D.E. In: Handbook of Clinical Ultrasound. New-York: John Willey and Sons, 1978, 335–43.\nMallory, A., Kern, F. Drug-induced pancreatitis: a critical review. Gastroenterology 1980, 78, 813–20.\nReynolds, J.C., Inman, R., Kimberg, R.P., Chuong, S.H., Kovacs, J.E., Walsh, M.B. Acute pancreatitis in systemic lupus disseminated. Report of twenty cases and a review of the literature. Medicine (Baltimore) 1982, 61, 25–33.\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nChevalier, X., Awada, H., Baetz, A. et al. Danazol induced pancreatitis and hepatitis. Clin Rheumatol 9, 239–241 (1990). https://doi.org/10.1007/BF02031976\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF02031976","source_license":"CC0","license_restricted":false}