Hysterectomy, non-malignant gynecological diseases, and the risk of incident hypertension: The E3N prospective cohort

Anne-Laure Madika, Anne‐Laure Madika, Madika AL, Conor James MacDonald, MacDonald CJ, Conor MacDonald, Amandine Gelot, Gelot A, Hitier S, S. Hitier, Sixtine Hitier, Claire Mounier-Vehier, Mounier-Vehier C, Claire Mounier‐Véhier, Guillaume Béraud, Marina Kvaskoff, Marie‐Christine Boutron‐Ruault, Marie-Christine Boutron-Ruault, Boutron-Ruault MC, Bonnet F, Fabrice Bonnet
Maturitas · 2021 · vol. 150 , pp. 22–29 · doi:10.1016/j.maturitas.2021.06.001 · PMID:34274072 · W3172481663
article OA: green CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

In a large prospective cohort study, hysterectomy, endometriosis, and uterine fibroids were each associated with an increased risk of developing hypertension.

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Abstract

ObjectivesWhile it has been reported that women with uterine fibroids or endometriosis are commonly overweight and hypertensive, the association between non-malignant gynecological diseases and the risk of hypertension has been little studied prospectively. The aim of this study was to investigate in a large French cohort of women whether a history of hysterectomy, uterine fibroids, or endometriosis was prospectively related to an increased risk of incident hypertension.Study designWe analyzed 50,286 women from the E3N cohort who were free of hypertension at baseline, with a median follow-up of 16.4 years.Main outcome measuresGynecological diseases were based on self-report. Cox proportional hazards models with age as the timescale were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Covariates included smoking status, body mass index (BMI), physical activity, and hormonal factors.ResultsA total of 12,073 women (24%) developed hypertension during follow-up. Women with a history of hysterectomy had an increased risk of incident hypertension, which persisted after adjustment for potential confounding factors (adjusted HR=1.18, 95% CI 1.12-1.24). Risk was similar in women with hysterectomy with or without oophorectomy. Risk of hypertension was higher in women with a history of endometriosis (HRendometriosis 1.19, 95%CI 1.11-1.22) or uterine fibroids (HRfibroids 1.18, 95%CI 1.13-1.22), irrespective of hysterectomy. Associations were similar after further adjustment for BMI.ConclusionsHysterectomy and non-malignant gynecological diseases were associated with an increased risk of hypertension in this large prospective study. Women with these conditions may benefit from blood pressure monitoring. ClinicalTrials.gov identifier: NCT03285230.
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MeSH descriptors

Body Mass Index Genital Diseases, Female Hypertension Hysterectomy Ovariectomy Adult Aged Female France France Genital Diseases, Female Humans Hypertension Hypertension Hypertension Hysterectomy Incidence Middle Aged Ovariectomy Prospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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