Assessment of Endometrial Perfusion with Doppler Ultrasound in Spontaneous and Stimulated Menstrual Cycles.

Akihito Nakai, Akishige Yokota, Tatsuo Koshino, Tsutomu Araki
In: Journal of Nippon Medical School · 2002 · vol. 69(4) , pp. 328–332 · doi:10.1272/jnms.69.328 · PMID:12187364 · W2126979646
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Doppler ultrasound revealed lower endometrial perfusion during the periovulatory period in clomiphene citrate stimulated cycles compared to spontaneous cycles.

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This study assessed endometrial perfusion using transvaginal color Doppler ultrasound by measuring blood flow waveforms in right and left uterine arteries in infertile women across 60 spontaneous menstrual cycles and 37 clomiphene citrate–stimulated cycles, followed from the follicular through the luteal phase. Uterine arterial blood flow increased significantly from the follicular phase to ovulation in spontaneous cycles and then rose markedly to about 200–230% of follicular levels after the 6th day of ovulation, whereas in clomiphene-stimulated cycles flow showed no change during the periovulatory period and increased to about 180–220% after the 6th day. The authors concluded that clomiphene stimulated cycles have lower periovulatory endometrial perfusion than spontaneous cycles, and they stated that Doppler assessment could help reveal unexplained infertility problems in induced ovarian cycles. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

OBJECTIVE: Endometrial perfusions were measured by Doppler ultrasound to evaluate the influence of spontaneous menstrual cycles and to study the effect of clomiphene citrate. METHODS: Flow waveforms in right and left uterine arteries were obtained by using transvaginal color Doppler ultrasonography in infertile women with 60 spontaneous menstrual cycles and 37 clomiphene citrate stimulated cycles from the follicular to the luteal phase. RESULTS: In the spontaneous menstrual cycles, the uterine arterial blood flow increased significantly from the follicular phase to the day of ovulation and then increased markedly to about 200 approximately 230% of the follicular phase after the 6th day of ovulation. In the clomiphene citrate stimulated cycles, the uterine arterial blood flow did not change during the periovulatory period and then increased significantly to about 180 approximately 220% of the follicular phase after the 6th day of ovulation. CONCLUSIONS: In the present study, the clomiphene citrate stimulated cycles showed lower endometrial perfusion during the periovulatory period compared with those in the spontaneous menstrual cycles. The results suggest that the assessment of endometrial perfusion with Doppler ultrasound can be used to reveal unexplained infertility problems in induced ovarian cycles.
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Abstract

Objective: Endometrial perfusions were measured by Doppler ultrasound to evaluate the influence of spontaneous menstrual cycles and to study the effect of clomiphene citrate.

Methods

Flow waveforms in right and left uterine arteries were obtained by using transvaginal color Doppler ultrasonography in infertile women with 60 spontaneous menstrual cycles and 37 clomiphene citrate stimulated cycles from the follicular to the luteal phase.

Results

In the spontaneous menstrual cycles, the uterine arterial blood flow increased significantly from the follicular phase to the day of ovulation and then increased markedly to about 200∼230% of the follicular phase after the 6th day of ovulation. In the clomiphene citrate stimulated cycles, the uterine arterial blood flow did not change during the periovulatory period and then increased significantly to about 180∼220% of the follicular phase after the 6th day of ovulation.

Conclusions

In the present study, the clomiphene citrate stimulated cycles showed lower endometrial perfusion during the periovulatory period compared with those in the spontaneous menstrual cycles. The results suggest that the assessment of endometrial perfusion with Doppler ultrasound can be used to reveal unexplained infertility problems in induced ovarian cycles.

Methods

Flow waveforms in right and left uterine arteries were obtained by using transvaginal color Doppler ultrasonography in infertile women with 60 spontaneous menstrual cycles and 37 clomiphene citrate stimulated cycles from the follicular to the luteal phase.

Results

In the spontaneous menstrual cycles, the uterine arterial blood flow increased significantly from the follicular phase to the day of ovulation and then increased markedly to about 200∼230% of the follicular phase after the 6th day of ovulation. In the clomiphene citrate stimulated cycles, the uterine arterial blood flow did not change during the periovulatory period and then increased significantly to about 180∼220% of the follicular phase after the 6th day of ovulation.

Conclusions

In the present study, the clomiphene citrate stimulated cycles showed lower endometrial perfusion during the periovulatory period compared with those in the spontaneous menstrual cycles. The results suggest that the assessment of endometrial perfusion with Doppler ultrasound can be used to reveal unexplained infertility problems in induced ovarian cycles. © 2002 by the Medical Association of Nippon Medical School Favorites & Alerts Recently viewed articles Predecessor

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