The Role of Nutrition in Pathogenesis of Uterine Fibroids

Jarosław Krzyżanowski, Tomasz Paszkowski, Sławomir Woźniak
Nutrients · 2023 · vol. 15(23) , pp. 4984 · doi:10.3390/nu15234984 · PMID:38068842 · PMC10708302 · W4389245373
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This scoping review examined literature on nutrition and uterine fibroids, finding preliminary evidence for beneficial effects of fruits and vegetables and a link between low vitamin D and increased fibroid risk.

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Abstract

Uterine fibroids are benign tumors that arise from the smooth muscle tissue of the uterus and are the most common tumors in women. Due to their high prevalence, costs for the health care system and the substantial impact on women's quality of life, they are a significant public health concern. Previous literature on the impact of diet on the occurrence, growth and symptoms of fibroids is limited. Recently, many papers have been written on this topic. A scoping review of PubMed and Cochrane databases was performed using the following keywords: uterine fibroids, antioxidants, diet, diet, vegetarian, vegetables, fruits, meat and soy foods, dairy products, tea, vitamin D, vitamin C, ascorbic acid. Preliminary research has shown a beneficial effect of vegetable and fruit consumption on the occurrence of fibroids. A relationship between hypovitaminosis D and an increased risk of fibroids has also been demonstrated. Studies on epigallocatechin gallate showed its apoptosis-promoting and antifibrinolytic effect in fibroid cells. Initial results are promising, but further randomized trials are needed to draw firm conclusions about the effects of diet and nutrients on uterine fibroids.

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MeSH descriptors

Leiomyoma Leiomyoma Uterine Neoplasms Uterine Neoplasms Uterine Neoplasms Ascorbic Acid Diet Diet Female Humans Quality of Life Vegetables Vitamins

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