Evaluation of Applications of Intrauterine Progesterone Versus Oral Progesterone in the Treatment of Dysfunctional Uterine Bleeding

Muhammad Jamil Johar, Nasreen Akhtar, Sara Akram, Farzana Sabir, Khunsa Rehman, Farzana Burki
In: Pakistan Journal of Medical and Health Sciences · 2023 · vol. 17(3) , pp. 328–330 · doi:10.53350/pjmhs2023173328 · W4367294484
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

This randomized controlled study found that intrauterine progesterone was more effective than oral progesterone in reducing bleeding duration and pad usage for women with dysfunctional uterine bleeding.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This randomized controlled study compared intrauterine progesterone versus oral progesterone for dysfunctional uterine bleeding in patients treated at two hospitals over six months. Using pad use and bleeding duration measured before and after treatment, the study found bleeding duration decreased in both groups, with intrauterine progesterone associated with shorter post-treatment bleeding days (5.9 vs 6.7) and lower post-study pad use (12.9 vs 18.7) than the oral group, with statistically significant differences reported. The paper’s main limitation is that it describes overall bleeding outcomes without detailing underlying etiologies, such as fibroids or endometriosis, for individual participants. Relevance to endometriosis: endometriosis is mentioned as one possible cause of abnormal uterine bleeding in the paper’s background, though the study’s focus is comparative routes of progesterone for dysfunctional uterine bleeding rather than endometriosis specifically.

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Abstract

Background: Abnormal uterine bleeding (AUB) is a common gynecological problem that affects the women of all ages. It is defined as any irregular or excessive bleeding from the uterus that is not related to the woman’s normal menstrual cycle. It can be caused by a many of underlying factors such as hormonal imbalance, fibroids, polyps or endometriosis. Study design: It is a randomized controlled study conducted at Divisional Headquarters Teaching Hospital Mirpur Azad Kashmir and Lady Willingdon Hospital Lahore for the duration of six months from June 2022 to November 2022. Material and Methods: The study was carried out for two groups. Intrauterine group included the patients that received intrauterine dose of progesterone and oral group patients had progesterone orally. The study was approved by the review board committee of the hospital. The use of pads for both groups was studied and it was found that oral group used the most pads 18.7 and 12.9 before and after the study respectively. Results: Duration of bleeding was examined. The patients in intrauterine group stated about bleeding for 7.8 days before the study and 5.9 days after the study. In case of oral group participants, they bled for 8.9 days before the study and 6.7 days after the study. Standard deviation and p value was calculated and results were statistically significant. Conclusion: The investigation of oral and intrauterine progesterone for patients suffering from dysfunctional uterine bleeding was studied and it was found that the rate of bleeding was more in case of oral group. Keywords: Intrauterine progesterone and oral progesterone.
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Background

Abnormal uterine bleeding (AUB) is a common gynecological problem that affects the women of all ages. It is defined as any irregular or excessive bleeding from the uterus that is not related to the woman’s normal menstrual cycle. It can be caused by a many of underlying factors such as hormonal imbalance, fibroids, polyps or endometriosis. Study design: It is a randomized controlled study conducted at Divisional Headquarters Teaching Hospital Mirpur Azad Kashmir and Lady Willingdon Hospital Lahore for the duration of six months from June 2022 to November 2022.

Material and methods

The study was carried out for two groups. Intrauterine group included the patients that received intrauterine dose of progesterone and oral group patients had progesterone orally. The study was approved by the review board committee of the hospital. The use of pads for both groups was studied and it was found that oral group used the most pads 18.7 and 12.9 before and after the study respectively.

Results

Duration of bleeding was examined. The patients in intrauterine group stated about bleeding for 7.8 days before the study and 5.9 days after the study. In case of oral group participants, they bled for 8.9 days before the study and 6.7 days after the study. Standard deviation and p value was calculated and results were statistically significant.

Conclusion

The investigation of oral and intrauterine progesterone for patients suffering from dysfunctional uterine bleeding was studied and it was found that the rate of bleeding was more in case of oral group.

Keywords

Intrauterine progesterone and oral progesterone.

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Condition tags

endometriosis

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