Endometriosis in Four Irradiated Rhesus Monkeys

Splitter GA, Gary A. Splitter, G A Splitter, Kirk JH, J H Kirk, John H. Kirk, William F. Mac Kenzie, Mac Kenzie WF, W F Mac Kenzie, Clarence A. Rawlings, C A Rawlings, Rawlings CA
Veterinary pathology · 1972 · vol. 9(4) , pp. 249–262 · doi:10.1177/030098587200900404 · PMID:4210689 · W2132424800
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Irradiation-exposed rhesus monkeys developed aggressive endometriosis, suggesting theories of pathogenesis in humans may not apply and potentially linking it to reproductive hormones and latent irradiation effects.

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Abstract

Four Rhesus monkeys that had been irradiated at 1 year of age and developed extensive endometriosis of the pelvic and peritoneal cavities 7 years later. Endometriosis was characterized by aggressive viable nonanaplastic endometrial epithelial cells in ectopic sites throughout the genital organs. Theories of pathogenesis for man may not be valid for nonhuman primates. Retrograde flow of endometrial fragments via the oviducts may be the source of the extrauterine lesions since in monkeys 1, 2, and 4 the ovaries were in the main extrauterine masses. Whether the extrauterine endometrium is metaplastic or metastatic, there is little doubt that endometriosis is linked to the cyclic hormones of the female's reproductive cycle. The cases reported occurred at 8 years of age, and the deaths may illustrate shortening of life as a latent effect of irradiation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Macaca Monkey Diseases Radiation Injuries, Experimental Animals Blood Urea Nitrogen Endometriosis Endometriosis Endometriosis Female Haplorhini Kidney Kidney Kidney Diseases Kidney Diseases Kidney Diseases Monkey Diseases Monkey Diseases Ovary Ovary

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