Expression of focal adhesion kinase in the eutopic endometrium of women with adenomyosis varies with dysmenorrhea and pelvic pain

Lin Mu, Wei‐Min Chen, Weimin Chen, Yanyan Ma, Wei Zheng
Experimental and therapeutic medicine · 2015 · vol. 10(5) , pp. 1903–1907 · doi:10.3892/etm.2015.2736 · PMID:26640570 · PMC4665385 · W2143753480
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Focal adhesion kinase (FAK) mRNA and protein expression were elevated in the eutopic endometrium of women with adenomyosis and correlated with dysmenorrhea and pelvic pain.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated whether focal adhesion kinase (FAK) expression differs in eutopic endometrium from women with adenomyosis versus women without adenomyosis, using immunohistochemistry, western blot, and reverse transcription-quantitative PCR in 47 reproductive-age participants. The authors found higher FAK mRNA and protein levels in the eutopic endometrium of adenomyosis patients, and they reported a positive correlation between FAK protein expression and the severity of dysmenorrhea and pelvic pain (P<0.05). A key limitation is that the study’s small, cross-sectional design cannot establish whether altered FAK expression is a cause or consequence of symptoms or adenomyosis pathology. This paper is centrally about endometriosis and adenomyosis — specifically, it examines FAK expression in the eutopic endometrium of women with adenomyosis and its association with dysmenorrhea and pelvic pain.

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Abstract

The aim of the present study was to examine whether the expression of focal adhesion kinase (FAK) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of FAK was assessed by immunohistochemical, western blot and reverse transcription-quantitative polymerase chain reaction analyses. An elevated expression of FAK mRNA and protein was identified in the eutopic endometrium of patients with adenomyosis compared with patients without adenomyosis (P<0.05). In addition, a positive correlation was detected between FAK protein expression and dysmenorrhea and pelvic pain in females with adenomyosis (P<0.05). The significant increase of FAK expression identified in the eutopic endometrium of females with adenomyosis, as well as the association of FAK protein expression with dysmenorrhea and pelvic pain, suggested that FAK may play a role in the pathogenesis of adenomyosis.

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adenomyosisdysmenorrhea

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