Endometrioma and Mature Cystic Teratoma as Collision Tumors of the Ovary: A Case Series and Literature Review

Fatma Başak Tanoğlu, Sultan Seren Karakuş, Sultan Seren Karakus, Resul Karakus, Resul Karakuş, Nilüfer Akgün, Nilufer Akgun, Yaprak Engin Üstün, Yaprak Engin Ustun, Seda Ates, Seda Ateş, Taner Usta, Engin Oral
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2025 · vol. 45(2) , pp. 142–151 · doi:10.1097/pgp.0000000000001147 · PMID:41217379 · W4416111917
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This case series and literature review describes 49 patients with collision tumors of endometrioma and mature cystic teratoma, detailing their clinical presentation, surgical management, and the critical need for accurate diagnosis to preserve ovarian function.

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Abstract

The simultaneous presence of distinct histologic types of ovarian cysts in a single patient, known as "collision tumors," presents a clinical challenge. In this study, we report 19 new cases of ovarian collision tumors involving both endometriomas and mature cystic teratomas (MCTs), and we review their characteristics alongside 30 previously reported cases. Among the total of 49 patients, the mean age was 32.28±8.07 yr, with 66.67% being nulliparous. The most common clinical symptom was abdominal pain (55.10%), while 12.24% were diagnosed incidentally. Primary infertility was identified in 14.28% of patients. Of the 44 cases with available surgical data, 32 underwent cystectomy and 12 underwent oophorectomy. In the 19 newly reported cases, 10 patients desired fertility preservation, yet only one achieved spontaneous pregnancy after surgery. Although both endometriomas and MCTs are benign ovarian lesions, their coexistence is rare. Tissue diagnosis is essential to exclude malignancy and guide follow-up, but preserving ovarian reserve is equally critical. Recognizing the presence of collision tumors can help physicians utilize radiologic methods more effectively and adopt a more proactive approach, safeguarding the future fertility and quality of life of these patients.

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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Ovarian Cysts Ovarian Cysts Ovarian Cysts Ovarian Cysts Ovarian Cysts Ovarian Cysts Ovarian Cysts Ovarian Cysts Ovarian Cysts

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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