Endometrioma and Mature Cystic Teratoma as Collision Tumors of the Ovary: A Case Series and Literature Review

Fatma Başak Tanoğlu, Sultan Seren Karakus, Karakus SS, Sultan Seren Karakuş, Resul Karakuş, Resul Karakus, Karakus R, Akgun N, Nilufer Akgun, Nilüfer Akgün, Ustun YE, Yaprak Engin Üstün, Yaprak Engin Ustun, Seda Ates, Seda Ateş, Ates S, Taner Usta, Usta T, Oral E, Engin Oral
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2025 · vol. 45(2) , pp. 142–151 · doi:10.1097/pgp.0000000000001147 · PMID:41217379 · W4416111917
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This case series and literature review describes 49 patients with collision tumors of endometrioma and mature cystic teratoma, detailing their clinical presentation, surgical management, and the critical need for accurate diagnosis to preserve ovarian function.

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Abstract

The simultaneous presence of distinct histologic types of ovarian cysts in a single patient, known as "collision tumors," presents a clinical challenge. In this study, we report 19 new cases of ovarian collision tumors involving both endometriomas and mature cystic teratomas (MCTs), and we review their characteristics alongside 30 previously reported cases. Among the total of 49 patients, the mean age was 32.28±8.07 yr, with 66.67% being nulliparous. The most common clinical symptom was abdominal pain (55.10%), while 12.24% were diagnosed incidentally. Primary infertility was identified in 14.28% of patients. Of the 44 cases with available surgical data, 32 underwent cystectomy and 12 underwent oophorectomy. In the 19 newly reported cases, 10 patients desired fertility preservation, yet only one achieved spontaneous pregnancy after surgery. Although both endometriomas and MCTs are benign ovarian lesions, their coexistence is rare. Tissue diagnosis is essential to exclude malignancy and guide follow-up, but preserving ovarian reserve is equally critical. Recognizing the presence of collision tumors can help physicians utilize radiologic methods more effectively and adopt a more proactive approach, safeguarding the future fertility and quality of life of these patients.
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The simultaneous presence of distinct histologic types of ovarian cysts in a single patient, known as “collision tumors,” presents a clinical challenge. In this study, we report 19 new cases of ovarian collision tumors involving both endometriomas and mature cystic teratomas (MCTs), and we review their characteristics alongside 30 previously reported cases. Among the total of 49 patients, the mean age was 32.28±8.07 yr, with 66.67% being nulliparous. The most common clinical symptom was abdominal pain (55.10%), while 12.24% were diagnosed incidentally. Primary infertility was identified in 14.28% of patients. Of the 44 cases with available surgical data, 32 underwent cystectomy and 12 underwent oophorectomy. In the 19 newly reported cases, 10 patients desired fertility preservation, yet only one achieved spontaneous pregnancy after surgery. Although both endometriomas and MCTs are benign ovarian lesions, their coexistence is rare. Tissue diagnosis is essential to exclude malignancy and guide follow-up, but preserving ovarian reserve is equally critical. Recognizing the presence of collision tumors can help physicians utilize radiologic methods more effectively and adopt a more proactive approach, safeguarding the future fertility and quality of life of these patients. Endometrioma and Mature Cystic Teratoma as Collision Tumors of the Ovary: A Case Series and Literature Review Plain Language SummaryThis study examines the rare occurrence of ovarian collision tumors, where two types of benign cysts, endometriomas and mature cystic teratomas (MCTs), coexist in a single patient. Among 49 cases, the average age was 32 years, with most patients experiencing abdominal pain. Surgical treatment varied, with cystectomy and oophorectomy being common. Despite the benign nature of these cysts, their combination poses challenges, particularly for fertility preservation. Only one patient achieved pregnancy post-surgery. Accurate diagnosis is crucial to rule out cancer and guide treatment, emphasizing the importance of preserving ovarian function and improving future fertility outcomes. Text is machine generated and may contain inaccuracies. FAQ

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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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