Assessment of risk factors for progression and recurrence of ovarian endometriosis

С А Леваков, Т.А. Громова, A.E. Mamedova
In: Russian Bulletin of Obstetrician-Gynecologist · 2023 · vol. 23(3) , pp. 127 · doi:10.17116/rosakush202323031127 · W4382242257
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study identified significant clinical and anamnestic risk factors for ovarian endometriosis recurrence and developed a mathematical formula for predicting recurrence likelihood.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The study retrospectively analyzed 126 reproductive-age patients with ovarian endometriosis who underwent planned laparoscopic cystectomy, comparing 84 with newly diagnosed disease versus 42 with recurrent disease, to identify clinical and anamnestic factors linked to progression and postoperative recurrence. Risk factors were assessed using patient histories, menstrual and obstetric/gynecologic background, comorbidities, BMI, smoking, stress, prior uterine procedures, histologic verification of endometriotic tissue, and postoperative endocrine therapy duration; recurrence was tracked by structured questionnaires, with prognostic modeling using (linear) regression due to correlated predictors. The strongest association with postoperative recurrence was reported for the extent of ovarian endometriosis, followed by history of intrauterine interventions and patterns of postoperative hormonal therapy, with smoking and arterial hypertension also showing strong correlations. The paper specifically relates to endometriosis (ovarian endometriosis), focusing on risk factors for progression and recurrence after surgery and the influence of clinical characteristics and postoperative hormonal treatment.

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Abstract

Objective. To determine the most significant clinical and anamnestic risk factors for the progression and postoperative recurrence of ovarian endometriosis, evaluate the effectiveness treatment to prevent post-surgical disease recurrence. Material and methods. 126 case histories of patients with diagnosed ovarian endometriosis were studied, which met the inclusion criteria. An analysis was made of clinical and anamnestic data, the results of the histological method of investigation after surgical treatment, as well as a specially designed questionnaire in order to obtain long-term results of treatment and identify risk factors for relapse in patients with ovarian endometriosis. The appointment of Buserelin-Depo reduced the frequency of recurrence during the observation period. Results. Taking into account the evaluation of the data obtained, the most likely risk factors for recurrence of ovarian endometriosis were identified, and, among other things, the corresponding mathematical formula for determining this risk was proposed. To assess the accuracy of forecasting, an ROC-curve was constructed. Conclusion. Based on the results of the study, the most significant risk factors are shown, and when using the derived mathematical formula, it is possible to predict the likelihood of recurrence of ovarian endometriosis, which makes it possible to timely identify a high risk group for the development of reccurence and predetermine the appropriate personalized management tactics, taking into account oncological alertness. It is necessary to prescribe treatment to prevent post-surgical disease recurrence with GnRH agnonists (Buserelin-Depo).

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endometriosis

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