Endometriosis and the Risk of Melanoma: A Shared Thread?

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AI-generated summary by claude@2026-06+body, 2026-06-08

This paper explores the potential shared mechanisms, specifically SIRT1's role in epithelial-mesenchymal transition, between endometriosis and melanoma.

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This is a short commentary titled “Endometriosis and the Risk of Melanoma: A Shared Thread?” rather than a full primary research study, and it discusses conceptual links between endometriosis and melanoma. The paper draws on prior work including a prospective cohort study reporting associations between endometriosis and skin cancer risk, and it highlights mechanistic themes raised in related studies involving pathways such as SIRT1/progesterone resistance, epithelial–mesenchymal transition, and melanoma cell biology. A key limitation is that, as a commentary, it does not present new experimental or clinical analyses, relying on the evidence base it references. Relevance to endometriosis: the paper is explicitly about endometriosis and frames its relationship to melanoma/skin cancer risk, drawing on published endometriosis–cancer evidence and shared molecular concepts.

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References Farland LV, Lorrain S, Missmer SA, Dartois L, Cervenka I, Savoye I, et al. Endometriosis and the risk of skin cancer: a prospective cohort study. Cancer Causes Control. 2017;28(10):1011–9. Kim TH, Young SL, Sasaki T, Deaton JL, Schammel DP, Palomino WA, et al. Role of SIRT1 and progesterone resistance in normal and abnormal endometrium. J Clin Endocrinol Metab. 2022;107(3):788–800. Sun T, Jiao L, Wang Y, Yu Y, Ming L. SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells. Cell Death Dis. 2018;9(2):136. Wilking MJ, Singh C, Nihal M, Zhong W, Ahmad N. SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. Arch Biochem Biophys. 2014;563:94–100. Wang M, Wu Y, He Y, Liu J, Chen Y, Huang J, et al. SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis. Sci Rep. 2022;12(1):12302. Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest The author declares no conflict of interest. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Dr. Raffaella Mormile: Pediatrician and Neonatologist, Division of Pediatrics and Neonatology, Moscati Hospital Aversa, Italy. Rights and permissions About this article Cite this article Mormile, R. Endometriosis and the Risk of Melanoma: A Shared Thread?. J Obstet Gynecol India 74, 562–563 (2024). https://doi.org/10.1007/s13224-024-02004-5 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s13224-024-02004-5

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