Endometriosis and the Risk of Melanoma: A Shared Thread?
This paper explores the potential shared mechanisms, specifically SIRT1's role in epithelial-mesenchymal transition, between endometriosis and melanoma.
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This is a short commentary titled “Endometriosis and the Risk of Melanoma: A Shared Thread?” rather than a full primary research study, and it discusses conceptual links between endometriosis and melanoma. The paper draws on prior work including a prospective cohort study reporting associations between endometriosis and skin cancer risk, and it highlights mechanistic themes raised in related studies involving pathways such as SIRT1/progesterone resistance, epithelial–mesenchymal transition, and melanoma cell biology. A key limitation is that, as a commentary, it does not present new experimental or clinical analyses, relying on the evidence base it references. Relevance to endometriosis: the paper is explicitly about endometriosis and frames its relationship to melanoma/skin cancer risk, drawing on published endometriosis–cancer evidence and shared molecular concepts.
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References (5)
- Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium via openalex
- SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis via openalex
- W1976907433 via openalex
- W2743607901 via openalex
- W2792052154 via openalex
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pmc
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- pubmed
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