Inhibiting CSNK2A Suppresses the Viability, Autophagy, Growth and Motility of Ectopic Endometrial Stromal Cells

Ming Li, M-Q Li, Li M, Meiling Sun, Junying Liu, Liu J, Xu Y, Yan Xu, Xue Zhao, Zhao X
Journal of biochemical and molecular toxicology · 2026 · vol. 40(6) , pp. e70897 · doi:10.1002/jbt.70897 · PMID:42257482 · W7163889173
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

CSNK2A1, highly expressed in endometriosis, was found to inhibit ectopic endometrial stromal cell viability, autophagy, growth, and motility by targeting the PI3K/Akt/mTOR pathway.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is an estrogen-dependent disorder characterized by ectopic growth of endometrial tissue. There is a lack of effective biomarkers for early detection and revealing mechanisms of endometriosis. CSNK2A1 is a compositionally active serine/threonine protein kinase that exerts its role by phosphorylating a variety of substrates, however, the role and mechanism of CSNK2A1 in endometriosis progression is still unclear. The aim of this study was to uncover the role of CSNK2A1 in endometriosis and elucidate the relevant mechanisms. Herein, we found CSNK2A1 is highly expressed in endometriosis. Its depletion inhibited the activity of ectopic endometrial stromal (ESC) cells. Further, knocking down of CSNK2A1 restrained the motility of ESC cells, and its ablation contributed to the autophagy of ESC cells. Mechanically, the depletion of CSNK2A1 blocked the PI3K/Akt/mTOR pathway in ESC cells. In summary, CSNK2A ablation inhibited the viability, autophagy, proliferation and invasion of ectopic endometrial stromal cells via targeting PI3K/Akt/mTOR pathway.

My notes (saved in your browser only)

MeSH descriptors

Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

SciLite annotations

chemicals 1
estrogen

Source provenance

europepmc
last seen: 2026-07-30T06:25:42.655704+00:00
openalex
last seen: 2026-07-30T06:08:59.260406+00:00
pubmed
last seen: 2026-07-30T06:12:02.314821+00:00
scilite
last seen: 2026-06-28T09:31:30.222730+00:00
License: CC0 · commercial use OK