Inhibiting CSNK2A Suppresses the Viability, Autophagy, Growth and Motility of Ectopic Endometrial Stromal Cells
article
OA: closed
CC0
Abstract
Endometriosis is an estrogen-dependent disorder characterized by ectopic growth of endometrial tissue. There is a lack of effective biomarkers for early detection and revealing mechanisms of endometriosis. CSNK2A1 is a compositionally active serine/threonine protein kinase that exerts its role by phosphorylating a variety of substrates, however, the role and mechanism of CSNK2A1 in endometriosis progression is still unclear. The aim of this study was to uncover the role of CSNK2A1 in endometriosis and elucidate the relevant mechanisms. Herein, we found CSNK2A1 is highly expressed in endometriosis. Its depletion inhibited the activity of ectopic endometrial stromal (ESC) cells. Further, knocking down of CSNK2A1 restrained the motility of ESC cells, and its ablation contributed to the autophagy of ESC cells. Mechanically, the depletion of CSNK2A1 blocked the PI3K/Akt/mTOR pathway in ESC cells. In summary, CSNK2A ablation inhibited the viability, autophagy, proliferation and invasion of ectopic endometrial stromal cells via targeting PI3K/Akt/mTOR pathway.
My notes (saved in your browser only)
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (23)
- CHCHD2 Regulates Mitochondrial Function and Apoptosis of Ectopic Endometrial Stromal Cells in the Pathogenesis of Endometriosis via openalex
- Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death via openalex
- Endometrial stromal cell autophagy-dependent ferroptosis caused by iron overload in ovarian endometriosis is inhibited by the ATF4-xCT pathway via openalex
- Endometriosis and the Risk of Melanoma: A Shared Thread? via openalex
- Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis via openalex
- Extracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis via openalex
- Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16- NK-cell differentiation via openalex
- Hypoxia Promotes Ectopic Adhesion Ability of Endometrial Stromal Cells via TGF-β1/Smad Signaling in Endometriosis via openalex
- Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis via openalex
- PI3K-Akt-mTOR and MAPK signaling pathways in polycystic ovarian syndrome, uterine leiomyomas and endometriosis: an update via openalex
- Silencing of circ_0007299 suppresses proliferation, migration, and invasiveness and promotes apoptosis of ectopic endometrial stromal cells in endometriosis via miR-424-5p-dependent modulation of CREB1 via openalex
- W4391290405 via openalex
- W4405782485 via openalex
- W2975552876 via openalex
- W2989997440 via openalex
- W3039118881 via openalex
- W3086007344 via openalex
- W3174958675 via openalex
- W3194097441 via openalex
- W4296293058 via openalex
- W4381598006 via openalex
- W4381850961 via openalex
- W4388793484 via openalex
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0
· commercial use OK