Endometrial changes in postmenopausal women treated with tamoxifen for breast cancer

Ilan Cohen, Doron J.D. Rosen, Jeremiah Shapira, Mario Cordoba, Shlomo Gilboa, Marco M. Altaras, Dror Yigael, Yoram Beyth
In: BJOG: An International Journal of Obstetrics & Gynaecology · 1993 · vol. 100(6) , pp. 567–570 · doi:10.1111/j.1471-0528.1993.tb15310.x · PMID:8334093 · W1971823947
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This cross-sectional study found no predictive risk factors for endometrial pathologies in asymptomatic postmenopausal breast cancer patients treated with tamoxifen, suggesting routine endometrial sampling is necessary.

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Abstract

OBJECTIVE: To evaluate whether risk factors, other than tamoxifen, can be identified for the development of endometrial pathologies in postmenopausal breast cancer patients treated with tamoxifen. DESIGN: A cross-sectional study. SETTING: Department of Obstetrics and Gynaecology and Oncology Clinic, Sapir Medical Center, Kfar Saba, Israel. SUBJECTS: 77 asymptomatic postmenopausal women, treated with tamoxifen for breast cancer. Of these, 55 had no endometrial tissue and 22 had endometrial tissue obtained by biopsy. MAIN OUTCOME MEASURES: Demographic characteristics, health habits, risk factors, vaginal ultrasonographic evaluations of endometrial thickness and texture, and histologic evaluations of endometrial biopsies. RESULTS: Overall, there was a high rate (29%) of endometrial pathological change among the 77 asymptomatic postmenopausal women. There were no significant statistical differences in the features tested between the two groups. CONCLUSION: It is impossible to predict which postmenopausal women will develop pathological endometrial changes after treatment with tamoxifen and thus a routine periodic endometrial sampling-follow up is suggested for all postmenopausal women being treated with this agent.

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