Could cells from menstrual blood be a new source for cell-based therapies?

Man-Jing Zhang, Manjing Zhang, Bin Liu, Wei Xia, Zhi-Yong Sun, Zhiyong Sun, Kaihua Lu, Kai-Hua Lu
Medical hypotheses · 2008 · vol. 72(3) , pp. 252–254 · doi:10.1016/j.mehy.2008.10.021 · PMID:19101090 · W2021012158
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Endometrial cells shed during menstruation exhibit high replicative and differentiation potential, making them a promising alternative source for cell-based therapies.

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Abstract

Human endometrium is a highly regenerative tissue and contains a low number of cells which have high replicative ability and differentiation efficiency. This has been identified by many scientists. When the fresh growth of tissue and blood vessels is shed during each menstrual cycle, some cells with regenerative capabilities are present. Reports have also indicated that these cells possess the capacity to trans-differentiate into mesodermal, ectodermal and endodermal lineages by using standard commercially available culture reagents and methodologies. Given the ease of extraction and pluripotency of this cell population, we propose it as a novel alternative to current cells sources for cell-based therapies.

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MeSH descriptors

Blood Cells Blood Component Transfusion Blood Component Transfusion Cell Transplantation Endometrium Menstruation Blood Cells Blood Component Transfusion Cell Transplantation Endometrium Female Humans Menstruation

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human

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