Effect of danazol on the pregnancy rate in patients with unsuccessful in vitro fertilization-embryo transfer.
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This prospective, randomized study found that danazol treatment increased the pregnancy rate in patients with repeated IVF-ET failures despite good embryo morphology.
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Abstract
OBJECTIVE: To determine the effect of danazol on in vitro fertilization-embryo transfer (IVF-ET) patients who failed to conceive in previous attempts despite having embryos with optimal morphology, whether endometriosis is present or not. STUDY DESIGN: In this prospective, randomized, controlled study, of 81 patients who experienced unexplained failures of IVF-ET despite having good-morphology embryos, 40 received danazol (400 mg/d orally for 12 weeks) following the unsuccessful IVF-ET cycle. The next IVF-ET was performed within three months of the first spontaneous ovulation after danazol administration. The remaining 41 patients constituted the control group, and in them the next IVF-ET was performed within six months after the previous failed cycle. RESULTS: Conception occurred in 16 of 40 (40%) danazol-treated patients at the subsequent cycle and showed a significant increase when compared with 8 of 41 (19.5%) control subjects (P < .05), though the number of embryos with optimal morphology decreased after danazol treatment. CONCLUSION: Danazol may be used for patients who have had repeated failures of IVF-ET despite having morphologically optimal embryos and may be useful for increasing receptivity of the endometrium in these patients.
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Cited by (7)
- Infertility Therapies: The Role of Assisted Reproductive Technologies 2011
- Is aromatase expression in the endometrium the cause of endometriosis and related infertility? 2009
- Effect of Danazol on NK Cells and Cytokines in the Mouse Uterus 2007
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2006
- Optimising in vitro fertilisation (IVF) outcome in women with endometriosis 2006
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2004
- Reduced Expression of αvβ3 Integrin in the Endometrium of Unexplained Infertility Patients with Recurrent IVF-ET Failures: Improvement by Danazol Treatment 2003
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
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- pubmed
- last seen: 2026-05-13T22:10:40.754221+00:00
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