Neuromodulatory approaches to chronic pelvic pain and coccygodynia

In: Acta Neurochirurgica Supplements · 2007 · pp. 365–371 · doi:10.1007/978-3-211-33079-1_48 · W182853710
article OA: closed CC0 ⤵ 5 in-corpus citations
Full text JSON View on OpenAlex View at publisher
AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-08

This paper reviews neuromodulatory treatments for chronic pelvic pain and coccygodynia, including nerve blocks, spinal cord stimulation, and peripheral nerve stimulation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text

This chapter reviews neuromodulatory and related interventions for intractable chronic pelvic pain and coccygodynia, describing approaches such as nerve blocks, trigger point injections, radiofrequency treatments, spinal cord and sacral stimulation, and peripheral nerve stimulation delivered transcutaneously, percutaneously, or via implants. It highlights the concept of targeting the “epicenter” of localized pain (including non-dermatomal distributions) by stimulating directly at peripherally affected painful areas, potentially bypassing spinal pathways and peripheral nerves. The key message is that targeted stimulation and peripheral nerve stimulation are “underused,” and that subcutaneous neuromodulation using miniaturized electrode technologies may refine and simplify treatment. The paper is a narrative chapter rather than presenting original clinical trial data or systematic outcome comparisons, limiting the ability to assess comparative effectiveness. Relevance to endometriosis: the chapter is focused on chronic pelvic pain generally and does not specifically discuss endometriosis as a treatment target, though its reference list includes studies examining pain behaviors in endometriosis-influenced animal models.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Intractable chronic pelvic pain (CPP) despite a multidisciplinary approach is challenging to treat. Every structure in the abdomen and/or pelvis could have a role in the etiology of CPP. Management of chronic pelvic pain may require a combination of interventions, including pharmacological, physical and psychological therapy. Interventions suggested to date include nerve blocks (ilioinguinal, iliohypogastric, genitofemoral, hypogastric, presacral) and trigger point injections, radiofrequency treatments, spinal cord stimulation (SCS), sacral root stimulation, sacral magnetic stimulation and sacral stimulation via tibial nerve. Peripheral nerve stimulation (PNS) has been particularly successful in the treatment of mononeuropathies. Indications for targeted stimulation include localised pain in non dermatomal distribution. Herein, the epicenter of the site of pain (target) is stimulated either transcutaneously or percutaneously or via permanent neuromodulating implant. Targeted and PNS probably are underused treatment modalities given the simplicity of the technique. The introduction of a stimulating electrode directly to the center of peripherally affected, painful areas, thereby bypassing the spinal cord and peripheral nerves is a novel simple procedure with effectiveness in the control of intractable neuropathic pain. Development of newer devices and miniaturization of electrodes will play a role in refinement and further simplification of subcutaneous neuromodulation.
Full text 7,295 characters · extracted from oa-doi-fallback · click to expand
Summary Intractable chronic pelvic pain (CPP) despite a multidisciplinary approach is challenging to treat. Every structure in the abdomen and/or pelvis could have a role in the etiology of CPP. Management of chronic pelvic pain may require a combination of interventions, including pharmacological, physical and psychological therapy. Interventions suggested to date include nerve blocks (ilioinguinal, iliohypogastric, genitofemoral, hypogastric, presacral) and trigger point injections, radiofrequency treatments, spinal cord stimulation (SCS), sacral root stimulation, sacral magnetic stimulation and sacral stimulation via tibial nerve. Peripheral nerve stimulation (PNS) has been particularly successful in the treatment of mononeuropathies. Indications for targeted stimulation include localised pain in non dermatomal distribution. Herein, the epicenter of the site of pain (target) is stimulated either transcutaneously or percutaneously or via permanent neuromodulating implant. Targeted and PNS probably are underused treatment modalities given the simplicity of the technique. The introduction of a stimulating electrode directly to the center of peripherally affected, painful areas, thereby bypassing the spinal cord and peripheral nerves is a novel simple procedure with effectiveness in the control of intractable neuropathic pain. Development of newer devices and miniaturization of electrodes will play a role in refinement and further simplification of subcutaneous neuromodulation. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Preview Unable to display preview. Download preview PDF. Similar content being viewed by others References Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, Wein A (2002) The standardisation of terminology of lower urinary tract function: report from the Standardisation Subcommittee of the International Continence Society. M J Obstet Gynecol 187: 116–126 Bennett DS, Brookoff D (2003) Sacral nerve root stimulation for interstitial cystitis. In: Simpson B (ed) Electrical stimulation and relief of pain in pain research and clinical management. Elsevier Science BV, Amsterdam pp 57–67 Berkley KJ (1997) Sex differences in pain. Behav Brain Sci 20: 371–380 Bjorling DE, Wang Z (2001) Estrogen and neuroinflammation. Urology 57Suppl 6A: 40–46 Campbell JN, Long DM (1976) Peripheral nerve stimulation in the treatment of intractable pain. J Neurosurg 45: 692–699 Derasari MD (2000) Taxonomy of pain syndromes: classification of chronic pain syndromes. In: Raj PP, Abrams BM, Benson HT et al (eds) Practical management of pain 3rd edn. Mosby Inc., St. Louis, pp 10–16 Fall M, Baranowski AP, Fowler CJ, Lepinard V, Malone Lee JG, Messelink EJ, Oberpenning F, Osborne JL, Schumacher S (2004) European Association of Urology. Guidelines on chronic pelvic pain. Eur Urol 46: 681–689 Giamberardino MA, Berkley KJ, Affaitati G, Lerza R, Centurione L, Lapenna D, Vecchiet L (2002) Influence of endometriosis on pain behaviours and muscle hyperalgesia induced by a ureteral calculosis in female rats. Pain 95: 247–257 Goroszeniuk T, Kothari S (2004) Targeted external area stimulation. Reg Anesth Pain Med 29Suppl 4: 98 Goroszeniuk T, Gorszeniuk K (2003) Short neuromodulation trial in neuropathic pain produces varying duration but reproducible pain relief. Pain in Europe IV. 4th Congress of EFIC, Prague, Sept. 2003. Abstract book p. 326, No. 494 T Goroszeniuk T (2003) Short term peripheral neuromodulation trial via stimulating catheter in neuropathic pain. Reg Anesth Pain Med 28Suppl 1: 64 Kothari S (2005) Short term neuromodulation trial in the treatment of coccygodynia. 7th Meeting of the International Neutomodualtion Society, Rome, June 2005 Kothari Sb (2005) Ilioinguinal/iliohypogastric nerve percutaneous stimulation for pelvic pain. 7th Meeting of the International Neutomodualtion Society, Rome, June 2005 Klingler HC, Pycha A, Schmidbauer J, Marberger M (2000) Use of peripheral neuromodulation of the S3 region for treatment of detrusor overactivity. Urology 56: 766–771 Krames E (2000) Using a pain treatment continuum: a logical and cost-effective approach. In: Raj PP, Abrams BM, Benson HT et al (eds) Practical management of pain, 3rd edn. Mosby Inc., St. Louis, pp 441–444 Leippold T, Strebel R, Huwyler M, Mirjam J, John H, Hauri D, Schmid D (2005) Sacral magnetic stimulation in non-inflammatory chronic pelvic pain syndrome. BJU Int 95: 838–841 Mathias SD, Kupperman M, Liberman RF Lipschutz RC, Steege JF (1996) Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol 87: 321–327 Mehik A, Leskinen Mj, Hellstrom P (2003) Mechanisms of pain in chronic pelvic pain syndrome: influence of prostatic inflammation. World J Urol 21: 90–94 Merskey H, Bogduk N (1994) Classification of chronic pain. Descriptions of chronic pain syndromes and definitions of pain terms, 2nd edn. IASP Press Pinter E, Szolcanyi J (1995) Plasma extravasation in the skin and pelvic organs evoked by antidromic stimulation of lumbosacral dorsal roots in the rat. Neuroscience 68: 603–614 Randic M, Jiang MC, Cerne R (1993) Long-term potientiation and long-term depression of primary afferent neurotransmission in rat spinal cord. Neurosci 13(12): 5228–5241 Raj PP (2000) Visceral pain. In: Raj PP, Abrams BM, Benson HT et al (eds) Practical management of pain 3rd edn. Mosby Inc., St. Louis, pp 223–239 Rowe E, Smith C, Laverick L, Elkabir J, Witherow R, Patel A (2005) A prospective, randomized, placebo controlled, double-blind study of pelvic electromagnetic therapy for the treatment of chronic pelvic pain syndrome with 1 year of follow up. J Urol 173: 2044–2047 Stanton-Hicks M (2003) Transcutaneous and peripheral nerve stimulation. In: Simpson BA (ed) Electrical stimulation and relief of pain, pain research and clinical management, vol. 15. Elsevier, Amsterdam, pp 37–55 Stinson LW, Roderer GT, Cross NE, Davis BE (2001) Peripheral subcutaneous electrostimulation for control of intractable post-operative inguinal pain: a case repot series. Neuromodulation 4: 99–104 Sun Y, Chai TC (2004) Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol 171: 448–452 Unruh AM (1996) Gender variations in clinical pain experience. Pain 65: 123–176 Zondervan KT, Yudkin PL, Vessey MP, Jenkinson CP, Dawes MG, Barlow DH, Kennedy SH (2001) The community prevalence of chronic pelvic pain in women and associated illness behaviour. Br J Gen Pract 51: 541–547 Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2007 Springer-Verlag About this chapter Cite this chapter Kothari, S. (2007). Neuromodulatory approaches to chronic pelvic pain and coccygodynia. In: Sakas, D.E., Simpson, B.A., Krames, E.S. (eds) Operative Neuromodulation. Acta Neurochirurgica Supplements, vol 97/1. Springer, Vienna. https://doi.org/10.1007/978-3-211-33079-1_48 Download citation DOI: https://doi.org/10.1007/978-3-211-33079-1_48 Publisher Name: Springer, Vienna Print ISBN: 978-3-211-33078-4 Online ISBN: 978-3-211-33079-1 eBook Packages: MedicineMedicine (R0)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

chronic_pelvic_pain

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

Cited by (3)

References (25)

Cited by (3)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-08-29T06:28:44.313744+00:00
License: CC0 · commercial use OK