Increased steroid receptor RNA activator protein (SRAP) accompanied by decreased estrogen receptor-beta (ER-β) levels during the malignant transformation of endometriosis associated ovarian clear cell carcinoma

Lin K, Kaiqing Lin, Zhan H, Hong Zhan, Ma J, Junyan Ma, Xu K, Kaihong Xu, Ruijin Wu, Wu R, Zhou C, Caiyun Zhou, Jun Lin, Lin J
Acta histochemica · 2014 · vol. 116(5) , pp. 878–882 · doi:10.1016/j.acthis.2014.02.007 · PMID:24704270 · W2068881251
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This study found that steroid receptor RNA activator protein (SRAP) levels increased while estrogen receptor-beta (ER-β) levels decreased during the malignant transformation of endometriosis-associated ovarian clear cell carcinoma.

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Abstract

The modulating attributes of steroid receptor RNA activator protein (SRAP) on steroid receptors have been shown in some types of tumor cells. There is compelling evidence to suggest that this molecule may play a critical role in the development of the tumor. However, little has been reported on its expression in endometriosis associated ovarian clear cell carcinoma (EAOCCC). In order to investigate the role of SRAP and estrogen receptors (ERs) in EAOCCC, we have analyzed the distribution of these proteins in the malignant transformation tissues and endometrioma tissues by immunohistochemistry. Our results revealed that the positive ratio of ER-β expression was gradually reduced during the malignant transformation from endometriosis to atypical endometriosis to clear cell carcinoma. Conversely, during the process, a gradual increase in SRAP expression was observed. Furthermore, there is a negative relationship between the expressions of these two molecules. Overall an increase in SRAP and a reduction in ER-β expression might be associated with malignant transformation of EAOCCC.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Cell Transformation, Neoplastic Endometriosis Estrogen Receptor beta Estrogen Receptor beta Estrogen Receptor beta Estrogen Receptor beta Gene Expression Regulation, Neoplastic Gene Expression Regulation, Neoplastic Ovarian Neoplasms RNA, Long Noncoding RNA, Long Noncoding RNA, Long Noncoding RNA, Long Noncoding Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Cited by (7)

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