Immunohistochemical study of HLA-DR antigen in endometrial tissue of patients with endometriosis

Yi Liu, Liu Y, Luo Lilan, Luo L, Lilan Luo, Haibo Zhao, Zhao H
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2002 · vol. 22(1) , pp. 60–61 · doi:10.1007/bf02904791 · PMID:12658786 · W2083182276
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-15 ⓘ

This study found significantly increased HLA-DR antigen expression in glandular cells of both eutopic and ectopic endometrial tissue from endometriosis patients compared to controls.

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This immunohistochemical study assessed expression of HLA-DR antigen in glandular cells in eutopic and ectopic endometrium from 19 infertile patients with endometriosis, using the labelled streptavidin biotin (LSAB) method, with 19 infertile patients without endometriosis as controls. The authors found significantly increased HLA-DR antigen expression in glandular cells in both eutopic and ectopic endometrium in the endometriosis group compared with controls (P<0.01). A key caveat is that the sample size is small and the work is descriptive, focusing on antigen expression without demonstrating mechanism or causal immunogenicity. Relevance to endometriosis: the paper is centrally about endometriosis—HLA-DR antigen expression in eutopic and ectopic endometrial tissue in patients with endometriosis.

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Abstract

In order to evaluate the expression of HLA-DR antigen in glandular cells in eutopic and ectopic endometrium in patients with endometriosis, 19 infertile patients with endometriosis were analyzed immunohistochemically by labelled streptavidin biotin (LSAB) method. Nineteen infertile patients without endometriosis were studied as controls. The results showed that the expression of HLA-DR antigen in the glandular cells in both eutopic and ectopic endometrium was increased significantly as compared with that in the controls (P < 0.01). It is likely that aberrant expression of HLA-DR antigen in endometriotic tissue is involved in abnormal immunogenesis of endometriosis.
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Summary In order to evaluate the expression of HLA-DR antigen in glandular cells in eutopic and ectopic endometrium in patients with endometriosis, 19 infertile patients with endometriosis were analyzed immunohistochemically by labelled streptavidin biotin (LSAB) method. Nineteen infertile patients without endometriosis were studied as controls. The results showed that the expression of HLA-DR antigen in the glandular cells in both eutopic and ectopic endometrium was increased significantly as compared with that in the controls (P<0.01). It is likely that aberrant expression of HLA-DR antigen in endometriotic tissue is involved in abormal immunogenesis of endometriosis. Similar content being viewed by others References Halme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am J Obstet Gynecol, 1984, 148: 85 Gleicher N. The role of humoral immunity in endometriosis. Acta Obstet Gynecol Scand Suppl, 1994, 159: 15 Gleicher N, Ei-Roeiy A, Confino Eet al. Is endometriosis an autoimmune disease? Obsete Gynecol, 1987, 70: 115 American Fertility Society. Revised American Fertility Society classification of endometriosis: 1985. Feril Steril, 1985, 43: 351 Hanafusa T, Fujino-Rurihara H, Miyazaki Aet al. Expression of class II major histocompatibility complex antigen on pancreatic B cells in the NOD mouse. Lancet, 1983, 11: 1115 Bottazzo G F, Dear B M, McNally I Met al. In situ characterization of autoimmune phenomena and expression of HLA molecules in the panereas in diabetic insulitis. N Engl J Med, 1985, 313: 353 Tabibzadeh S S, Bettica A, Gerber M A. Variable expression of Ia antigens in human endometrium and in chronic endometritis. Am J Clin Pathol, 1986, 86: 153 Kreiner D, Fromowitz F B, Richardson D Aet al. Endometrial immunofluorescence associated with endometriosis and pelvic inflammatory disease. Fertil Steril, 1986, 46: 243 Ota H, Maki M. content of immunoglobulin G and complent components C3 and C4 in endometriotic tissue or endometrium in women with adenomyosis or endometriosis. Med Sci Res, 1990, 18: 727 Ota H, Igarashi S. Expression of major histocompatibility complex class II antigen in endometriotic tissue in patients with endometriosis and adenomyosis. Fertil Steril, 1993, 60: 834 Author information Authors and Affiliations Additional information Liu Yi, male, born in 1968, Associate Professor Rights and permissions About this article Cite this article Yi, L., Lilan, L. & Haibo, Z. Immunohistochemical study of HLA-DR antigen in endometrial tissue of patients with endometriosis. Current Medical Science 22, 60–61 (2002). https://doi.org/10.1007/BF02904791 Received: Published: Issue date: DOI: https://doi.org/10.1007/BF02904791

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium HLA-DR Antigens Infertility Adult Endometriosis Endometriosis Endometrium Female HLA-DR Antigens Humans Immunohistochemistry Infertility Infertility Pelvis

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