{"paper_id":"6a8ce212-8b14-4236-a559-cc60497ba4a8","body_text":"Summary\nIn order to evaluate the expression of HLA-DR antigen in glandular cells in eutopic and ectopic endometrium in patients with endometriosis, 19 infertile patients with endometriosis were analyzed immunohistochemically by labelled streptavidin biotin (LSAB) method. Nineteen infertile patients without endometriosis were studied as controls. The results showed that the expression of HLA-DR antigen in the glandular cells in both eutopic and ectopic endometrium was increased significantly as compared with that in the controls (P<0.01). It is likely that aberrant expression of HLA-DR antigen in endometriotic tissue is involved in abormal immunogenesis of endometriosis.\nSimilar content being viewed by others\nReferences\nHalme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am J Obstet Gynecol, 1984, 148: 85\nGleicher N. The role of humoral immunity in endometriosis. Acta Obstet Gynecol Scand Suppl, 1994, 159: 15\nGleicher N, Ei-Roeiy A, Confino Eet al. Is endometriosis an autoimmune disease? Obsete Gynecol, 1987, 70: 115\nAmerican Fertility Society. Revised American Fertility Society classification of endometriosis: 1985. Feril Steril, 1985, 43: 351\nHanafusa T, Fujino-Rurihara H, Miyazaki Aet al. Expression of class II major histocompatibility complex antigen on pancreatic B cells in the NOD mouse. Lancet, 1983, 11: 1115\nBottazzo G F, Dear B M, McNally I Met al. In situ characterization of autoimmune phenomena and expression of HLA molecules in the panereas in diabetic insulitis. N Engl J Med, 1985, 313: 353\nTabibzadeh S S, Bettica A, Gerber M A. Variable expression of Ia antigens in human endometrium and in chronic endometritis. Am J Clin Pathol, 1986, 86: 153\nKreiner D, Fromowitz F B, Richardson D Aet al. Endometrial immunofluorescence associated with endometriosis and pelvic inflammatory disease. Fertil Steril, 1986, 46: 243\nOta H, Maki M. content of immunoglobulin G and complent components C3 and C4 in endometriotic tissue or endometrium in women with adenomyosis or endometriosis. Med Sci Res, 1990, 18: 727\nOta H, Igarashi S. Expression of major histocompatibility complex class II antigen in endometriotic tissue in patients with endometriosis and adenomyosis. Fertil Steril, 1993, 60: 834\nAuthor information\nAuthors and Affiliations\nAdditional information\nLiu Yi, male, born in 1968, Associate Professor\nRights and permissions\nAbout this article\nCite this article\nYi, L., Lilan, L. & Haibo, Z. Immunohistochemical study of HLA-DR antigen in endometrial tissue of patients with endometriosis. Current Medical Science 22, 60–61 (2002). https://doi.org/10.1007/BF02904791\nReceived:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/BF02904791","source_license":"CC0","license_restricted":false}