Risk of depressive disorders in women undergoing hysterectomy: A population-based follow-up study

Po‐Han Chou, Po-Han Chou, Ching-Heng Lin, Ching‐Heng Lin, Chin Cheng, Chia-Li Chang, Chia-Jui Tsai, Ching‐Pei Tsai, Ching-Pei Tsai, Tsuo-Hung Lan, Tsuo‐Hung Lan, Chin-Hong Chan
Journal of psychiatric research · 2015 · vol. 68 , pp. 186–191 · doi:10.1016/j.jpsychires.2015.06.017 · PMID:26228418 · W1836320139
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This population-based follow-up study investigated the risk of depressive disorders in women who underwent hysterectomy.

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Abstract

OBJECTIVE: The objective of this study was to assess the risk of depressive disorders in women who underwent hysterectomy in Taiwan. METHODS: A retrospective study was conducted in a matched cohort of cases using the National Health Insurance Research Database of Taiwan. Database records from 1689 women who underwent hysterectomy between 2001 and 2005 were included in this study. A control group matched for age and physical comorbidity was selected from the same database (n = 6752). For all cases, medical records were tracked until the end of 2009 to identify whether a depressive disorder was diagnosed during the follow-up period. The hazard ratio (HR) for depression during the observation period was analyzed using multivariable Cox proportional-hazards models, adjusted for age, physical comorbidities, and other socioeconomic factors. RESULTS: The HR for depression was 1.78 times higher for the group that underwent hysterectomy than for the control group (adjusted HR = 1.78; 95% CI = 1.46-2.18, p < 0.001). In addition, HR for major depressive disorder in women who underwent hysterectomy was significantly higher (1.84 times) than for the control group (adjusted HR = 1.84; 95% CI = 1.23-2.74, p < 0.01). CONCLUSIONS: Our study revealed that, in Taiwan, women who underwent hysterectomy had an increased risk of developing depression. Longitudinal studies to follow-up the psychological outcomes in Taiwanese women who underwent hysterectomy will be necessary to confirm our findings.

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MeSH descriptors

Depressive Disorder Hysterectomy National Health Programs Adult Depressive Disorder Depressive Disorder Female Follow-Up Studies Humans Hysterectomy Hysterectomy Middle Aged National Health Programs Taiwan Taiwan Young Adult

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