Effects of an extended-interval dosing regimen of triptorelin depot on the hormonal profile of patients with endometriosis: prospective observational study

C Y Tse, Tse CY, A M Chow, Chow AM, Chan SC, S C Chan
Hong Kong medical journal = Xianggang yi xue za zhi · 2000 · vol. 6(3) , pp. 260–4 · PMID:11025843 · W2114859746
Observational OA: closed CC0 ⤵ 9 in-corpus citations
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This study found that a 6-weekly triptorelin depot regimen effectively suppressed gonadotropins and ovarian steroids, reducing pain in endometriosis patients similarly to the conventional 4-weekly regimen.

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Abstract

OBJECTIVE: To evaluate the suppression of pituitary gonadotrophins and ovarian steroid hormone with the administration of triptorelin depot at 6-weekly intervals. DESIGN: Prospective observational study. SETTING: Obstetrics and gynaecology department of a public hospital, Hong Kong. PATIENTS: Consecutive patients with endometriosis, as diagnosed by laparoscopy or laparotomy from June 1998 through February 1999. INTERVENTION: Administration of four doses of triptorelin depot 3.75 mg either subcutaneously or intramuscularly every 6 weeks (21 patients), or conventional 4-weekly six-dose regimen (five patients). MAIN OUTCOME MEASURES: Serum levels of 17-beta-oestradiol, luteinizing hormone, and follicle-stimulating hormone; and pelvic pain symptoms. RESULTS: For the patients receiving the extended-interval dosing regimen of triptorelin, the levels of oestradiol and luteinizing hormone, and the pain score were significantly reduced throughout the treatment period and up to 10 weeks after the injection of the last dose. The level of follicle-stimulating hormone increased slowly but was still significantly lower than pretreatment levels. The hormonal profile was similar to that of patients receiving the conventional regimen. CONCLUSION: The use of the extended-interval dosing regimen of triptorelin depot results in a consistent hypo-oestrogenised state, which is similar to that achieved by the conventional regimen and which would be considered satisfactory for the medical treatment of pelvic endometriosis. The new regimen thus reduces the cost of treatment without compromising the effect on hormonal suppression.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Luteinizing Hormone Luteolytic Agents Triptorelin Pamoate Adult Adult Endometriosis Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Humans Luteinizing Hormone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (3)

Cited by (9)

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