Platelet-activating factor acetylhydrolase activity in peritoneal fluids of women with endometriosis

Hemmings R, Robert Hemmings, R Hemmings, Pierre Miron, Miron P, P Miron, Tommaso Falcone, Falcone T, T. Falcone, Jacques Bourque, J Bourque, Bourque J, Lepage N, N Lepage, Nathalie Lepage, Langlais J, J. Langlais
Obstetrics and gynecology · 1993 · vol. 81(2) , pp. 276–9 · PMID:8423963 · W2471912157
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Platelet-activating factor acetylhydrolase activity was significantly lower in the peritoneal fluids of women with mild endometriosis compared to fertile controls.

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Abstract

OBJECTIVE: To investigate whether platelet-activating factor acetylhydrolase may play a role in the pathophysiology of endometriosis. METHODS: Peritoneal fluids were obtained at laparoscopy from eight fertile women without endometriosis and 12 women with mild endometriosis. Platelet-activating factor acetylhydrolase activity was assayed in serum and peritoneal fluid by the release of 3H-acetate from [3H]-platelet-activating factor during a 15-minute incubation. RESULTS: Platelet-activating factor acetylhydrolase activity (mean +/- standard error of the mean) was significantly lower (P < .01) in peritoneal fluids from women with mild endometriosis (29.5 +/- 2.7%) than in controls (39.9 +/- 3.4%). The platelet-activating factor acetylhydrolase-cholesterol and -albumin ratios were also significantly lower in peritoneal fluids of women with endometriosis compared with controls (P < .006 and P < .012, respectively). CONCLUSION: These data suggest that mild endometriosis is associated with decreased platelet-activating factor acetylhydrolase activity in peritoneal fluid.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Phospholipases A Platelet Activating Factor 1-Alkyl-2-acetylglycerophosphocholine Esterase 1-Alkyl-2-acetylglycerophosphocholine Esterase Adult Adult Albumins Albumins Albumins Ascitic Fluid Ascitic Fluid Ascitic Fluid Cholesterol Cholesterol Cholesterol Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (5)

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