Platelet-activating factor acetylhydrolase activity in peritoneal fluids of women with endometriosis.
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Platelet-activating factor acetylhydrolase activity was significantly lower in the peritoneal fluids of women with mild endometriosis compared to fertile controls.
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Abstract
OBJECTIVE: To investigate whether platelet-activating factor acetylhydrolase may play a role in the pathophysiology of endometriosis. METHODS: Peritoneal fluids were obtained at laparoscopy from eight fertile women without endometriosis and 12 women with mild endometriosis. Platelet-activating factor acetylhydrolase activity was assayed in serum and peritoneal fluid by the release of 3H-acetate from [3H]-platelet-activating factor during a 15-minute incubation. RESULTS: Platelet-activating factor acetylhydrolase activity (mean +/- standard error of the mean) was significantly lower (P < .01) in peritoneal fluids from women with mild endometriosis (29.5 +/- 2.7%) than in controls (39.9 +/- 3.4%). The platelet-activating factor acetylhydrolase-cholesterol and -albumin ratios were also significantly lower in peritoneal fluids of women with endometriosis compared with controls (P < .006 and P < .012, respectively). CONCLUSION: These data suggest that mild endometriosis is associated with decreased platelet-activating factor acetylhydrolase activity in peritoneal fluid.
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Cited by (5)
- The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis 2023
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Endometriotic disease: the role of peritoneal fluid 1998
- Review of Peritoneal Factors that Affect Fertility in Patients With Mild Endometriosis 1996
- The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro 1996
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