Natural products: Potential lead compounds for the treatment of endometriosis

Machairiotis N, Nikolaos Machairiotis, Sofia Vasilakaki, Vasilakaki S, Kouroutou P, Paraskevi Kouroutou
European journal of obstetrics, gynecology, and reproductive biology · 2019 · vol. 245 , pp. 7–12 · doi:10.1016/j.ejogrb.2019.11.019 · PMID:31835203 · W2990750946
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This paper reviews natural products identified as potential lead compounds for the development of novel therapeutic treatments for endometriosis.

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Abstract

OBJECTIVE: Medical plants have been used for centuries for the treatment of various disorders in humans and animals. The therapeutic properties of herbs and plants have been documented for years, giving rise to ethnobotany, and have been a source for the development of novel drugs. Natural products usually have more than one pharmaceutical effects, due to the fact that they interact with more than one biological targets. This property could be used for the efficient treatment of diseases with multiple putative physiopathologic mechanisms, such as endometriosis. STUDY DESIGN: In the current study, we search the literature to find recent progress in the identification of compounds, which derived from plants and herbs and have therapeutic properties against endometriosis and its symptoms. The Scopus and PubMed databases were used to search for original articles, published between January 2018 and July 2019. The words "endometriosis", "pain", "treatment", "medication" were used for the query. RESULTS AND CONCLUSION: 14 compounds derived from plants and herbs have demonstrated pharmaceutical activity in experiments, including animal models and human endometriotic samples. The experimental data evidence the therapeutic effect of several natural products against endometriosis. Given that most of them are already well known for their pharmaceutical properties, these compounds should be used as leads for the development of novel drugs for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Phytotherapy Phytotherapy Plant Preparations Plants, Medicinal Plants, Medicinal Adult Adult Animals Animals Endometriosis Endometriosis Female Female Humans Humans Plant Preparations Plant Preparations Treatment Outcome Treatment Outcome

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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