MORPHOLOGICAL FEATURES OF ESTROGEN AND PROGESTERONE EXPRESSION LEVELS IN ECTOPIC ENDOMETRIUM IN WOMEN WITH ENDOMETRIAL CYSTS

Clinical medicine MORPHOLOGICAL FEATURES OF ESTROGEN AND PROGESTERONE EXPRESSION LEVELS IN ECTOPIC ENDOMETRIUM IN WOMEN WITH ENDOMETRIAL CYSTS Published 2021-08-30 Authors: NR N.M. Rozhkovska IG I.Z. Gladchuk IK I.A. Kobylyanska LR L.G. Rosha AG A.O. Gavrilyuk DS D.S. Sukhan AK A.L. Kostjuk - Abstract: - Endometrial cysts occupy one of the leading positions among endometrial neoplasms (up to 30 % of women of reproductive age have a history of this disease). The purpose of the study was to evaluate the immunomorphological features of ovarian endometrial tissue in women with infertility to assess their prognostic and diagnostic value. Our study has shown lower levels of estrogen and progesterone receptors in eutopic endometrium in women with ovarian endometrial cysts than in women without genital pathology. We associate this with the expression variants of the ER and PR receptor systems. In the main group, this ratio was 1 (11 out of 50 women had a characteristic histochemical picture for this pathology); in the comparison group, this figure was 14 cases out of 50, and in the control group – in 18 patients out of 50 studied. This allows us to consider the problem of sex hormones dysregulation as a predictor and, at the same time, a potential point of influence on the pathogenesis of cysts of endometrial origin. - Keywords: - endometrial cyst infertility estrogen receptor progesterone receptor - References: - - Afinogenova EA, Cherstvyj ED. Aktivnyi i neaktivnyi adenomioz: sravnitelnyi analiz v ochagakh ektopicheskogo endometriya (ekspressiya aromatazy Р-450, retseptorov estrogenov A i V, retseptorov progesterona). Vestnik obrazovaniya i razvitiya nauki Rossiyskoy akademii yestestvennykh nauk. 2016; 20(2): 74–82. [in Russian] - Benyuk VO, Goncharenko VM. 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