Preparation of the endometrium for ablation with a single dose of leuprolide acetate depot
Non-randomised trial
OA: closed
CC0
⤵ 5 in-corpus citations
AI-generated summary
A single 7.5 mg depot injection of leuprolide acetate administered pre-ablation thinned the endometrium, reduced its vascularity, and induced atrophy in eight women.
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Abstract
Several reports describe enhancing the efficacy of laser or resectoscopic endometrial ablation procedures by preparing the endometrium with danazol or progestin therapy. Because gonadotropin releasing hormone agonists have been found to inhibit the thickness and development of the endometrial lining, preparation of the endometrium for resectoscopic ablation was attempted on eight women using a single injection of 7.5 mg of leuprolide acetate depot. When the ablation was performed, one month after the injection of the medication, which had occurred on day 20-24 of the prior menstrual cycle, the endometrium was thinned in all the patients, with inactive glands, reduced vascularity and atrophic stroma.
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Cited by (5)
- Gestrinone versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation 2006
- Is endometrial pre-treatment of value in improving the outcome of transcervical resection of the endometrium? 2000
- Hormonal inhibition of endometrium for transcervical endometrial ablation--a prospective study with a 2-year follow-up 1997
- Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders 1994
- Evaluation of surgical options in menorrhagia 1994
Source provenance
- openalex
- last seen: 2026-05-10T10:29:58.231670+00:00
- pubmed
- last seen: 2026-10-08T21:06:23.467768+00:00
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