Editorial: Comorbidities in Women With Endometriosis: Risks and Implications

Sarah J Holdsworth-Carson, Sarah J. Holdsworth‐Carson, Cecilia H M Ng, Cecilia Ng, Dior UP, Uri P Dior
Frontiers in reproductive health · 2022 · vol. 4 , pp. 875277 · doi:10.3389/frph.2022.875277 · PMID:36303646 · PMC9580694 · W4283591287
editorial OA: gold CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper highlights the challenges in diagnosing endometriosis due to overlapping symptoms and discusses the high incidence of comorbidities observed in women with the condition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This editorial introduces a research topic focused on evidence for comorbid and chronic conditions in women with endometriosis, covering both non-gynecological and gynecological comorbidities. It highlights genetic analyses linking endometriosis to female melanoma risk, a quasi-systematic review finding limited and outdated evidence for associations with food hypersensitivities, a pain-focused review describing peripheral, central, and cross-sensitization across endometriosis-associated pain and comorbid pain syndromes, and reviews on endometriosis–fibroid comorbidity and obstetric outcomes after pre-pregnancy endometriosis surgery. A key limitation explicitly noted across included work is that evidence is often limited, outdated, or at risk of critical bias, preventing reliable conclusions—especially regarding surgery and adverse obstetric outcomes. This paper is centrally about endometriosis — it synthesizes and discusses research on comorbidities, risks, and implications affecting women with endometriosis.

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Abstract

Women with endometriosis suffer lengthy diagnostic delay. In part, this is the consequence of nonspecific and overlapping symptomology with common gynaecological and other diseases. As such, endometriosis may be confused or misdiagnosed as an entirely different condition. The challenge for health professionals is increased further by growing observations indicating that people with endometriosis also demonstrate a high incidence of gynaecological and non-gynaecological comorbidities and chronic conditions. The aim of our Research Topic was to highlight existing evidence-based research, or lack thereof, that aligns comorbid and chronic conditions with endometriosis.
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All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

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Coi Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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License: CC0 · commercial use OK