Frontiers in reproductive health

INTRODUCTION: Advanced maternal age (AMA) and assisted reproductive technologies (ART) are becoming more common and are linked with higher obstetric and perinatal risks. Genomic tools and real-world data (RWD) are transforming risk predicti…

OBJECTIVES: To determine whether anogenital distance (AGD), a potential non-invasive biomarker reflecting prenatal androgen exposure, differs between adolescents with laparoscopically confirmed endometriosis and matched controls. METHODS: …

INTRODUCTION: Infertility treatment may be influenced by systemic metabolic and redox imbalances. This prospective observational (cross-sectional) study aimed to evaluate the impact of clinical risk factors on oxidative stress markers and c…

Uterine rupture is a rare but life-threatening obstetric emergency, with most cases occurring during late pregnancy or labor, particularly in patients with a history of uterine surgery. This report presents an exceptionally rare case of spo…

An 18-year-old patient with an intact hymen presented with severe, cyclical dysmenorrhea, representing a common diagnostic challenge. Initial evaluation at an outside institution, including transabdominal ultrasound (TAUS) and magnetic reso…

BACKGROUND: Gender-affirming hysterectomies (GAH) are increasingly performed among transgender and gender-diverse (TGD) individuals, many of whom utilize testosterone. The World Professional Association for Transgender Health (WPATH) guidel…

This narrative review explores contemporary therapeutic options and critically assesses surgical results and in vitro fertilization-intracytoplasmic sperm injection (IVF/ICSI) outcomes in women affected by endometriosis, deep infiltrating e…

BACKGROUND: Cryopreservation is widely used across the life sciences to enable long-term storage of living cells and tissues for research or later clinical use. Its core principle is the arrest of biological activity at extremely low temper…

Adenomyosis is an estrogen-dependent uterine disorder increasingly recognized as a major cause of infertility and adverse obstetric outcomes, yet optimal medical preparation before embryo transfer (ET) remains uncertain. Adenomyotic lesions…

OBJECTIVE: We aimed to investigate the effect of seasons on embryo quality and pregnancy outcomes among infertile patients undergoing in vitro fertilization-embryo transfer (IVF-ET)-assisted pregnancy. METHODS: We retrospectively analyzed …

BACKGROUND: Endometriosis is a common gynecologic condition in which pelvic MRI plays an important role in diagnosis and preoperative assessment. AI-enabled automated uterus segmentation on pelvic MRI could support endometriosis care by ena…

Endometrial dysfunction represents a central pathological factor underlying recurrent implantation failure and infertility. This review provides a comprehensive synthesis of the physiological basis of endometrial function, the pathological …

INTRODUCTION: Endometrial thickness is a crucial indicator for reproductive health evaluation and initial detection of abnormalities. This study aims to comprehensively characterize and evaluate the endometrium in normal and cancer of Indon…

BACKGROUND: Fertility preservation is the process of saving or protecting a person's reproductive substance of human origin intended to be used later in that person's life. Fertility preservation technologies have benefits and risks. Among …

INTRODUCTION AND AIMS: Fertility preservation refers to the cryopreservation of gametes, embryos, or gonadal tissue before age, disease, or medical treatment affects reproductive capacity. Fertility preservation techniques were originally d…

With the rapid progression of urbanization and the widespread adoption of nocturnal work and lifestyle patterns, artificial light at night (ALAN) has emerged as a significant environmental factor impacting women's health. Current research s…

OBJECTIVE: To compare the effects of frozen-thawed embryo transfer at different times after hysteroscopic endometrial polyp resection on pregnancy outcomes and to provide evidence for individualized clinical treatment. METHODS: This study …

INTRODUCTION: Retained products of conception (rPOC) are a common complication following early pregnancy loss (EPL) and may contribute to infertility and delays in subsequent fertility treatment. Oral contraceptive pills (OCPs) are frequent…

INTRODUCTION: Endometriosis is a chronic gynecological disease associated with pelvic pain, infertility, and reduced quality of life. Ovarian endometrioma is its most common manifestation. Although laparoscopic cystectomy is widely used, co…

BACKGROUND: Declining fertility rates are a globally documented problem, affecting even regions that have historically high fertility rates. In the Asia Pacific (APAC) region, most countries and territories are seeing birth rates drop far b…

PURPOSE: To determine whether intracytoplasmic sperm injection (ICSI) improves cumulative live birth rates (cLBR) compared with conventional IVF among patients with non-male factor infertility. METHODS: This descriptive retrospective cohor…

BACKGROUND: Isolated fallopian tube torsion (IFTT) is a rare gynecologic emergency that frequently presents with nonspecific symptoms and may mimic other causes of acute abdominal pain, resulting in diagnostic delay. CASE PRESENTATION: A 5…

Impact statement: A legislatively mandated, statewide endometriosis biorepository integrated within a multidisciplinary endometriosis focused program demonstrates how policy-driven infrastructure can integrate education, clinical care, harm…