Frontiers in reproductive health

IntroductionAdvanced maternal age (AMA) and assisted reproductive technologies (ART) are becoming more common and are linked with higher obstetric and perinatal risks. Genomic tools and real-world data (RWD) are transforming risk prediction…

IntroductionInfertility treatment may be influenced by systemic metabolic and redox imbalances. This prospective observational (cross-sectional) study aimed to evaluate the impact of clinical risk factors on oxidative stress markers and com…

Uterine rupture is a rare but life-threatening obstetric emergency, with most cases occurring during late pregnancy or labor, particularly in patients with a history of uterine surgery. This report presents an exceptionally rare case of spo…

An 18-year-old patient with an intact hymen presented with severe, cyclical dysmenorrhea, representing a common diagnostic challenge. Initial evaluation at an outside institution, including transabdominal ultrasound (TAUS) and magnetic reso…

BackgroundGender-affirming hysterectomies (GAH) are increasingly performed among transgender and gender-diverse (TGD) individuals, many of whom utilize testosterone. The World Professional Association for Transgender Health (WPATH) guidelin…

This narrative review explores contemporary therapeutic options and critically assesses surgical results and in vitro fertilization-intracytoplasmic sperm injection (IVF/ICSI) outcomes in women affected by endometriosis, deep infiltrating e…

BackgroundCryopreservation is widely used across the life sciences to enable long-term storage of living cells and tissues for research or later clinical use. Its core principle is the arrest of biological activity at extremely low temperat…

Adenomyosis is an estrogen-dependent uterine disorder increasingly recognized as a major cause of infertility and adverse obstetric outcomes, yet optimal medical preparation before embryo transfer (ET) remains uncertain. Adenomyotic lesions…

ObjectiveWe aimed to investigate the effect of seasons on embryo quality and pregnancy outcomes among infertile patients undergoing in vitro fertilization-embryo transfer (IVF-ET)-assisted pregnancy.MethodsWe retrospectively analyzed data f…

ObjectiveThe purpose of this study was to evaluate the efficacy and safety of Nalbuphine compared to Pethidine for pain relief during oocyte retrieval.MethodsIn a double-blinded, non-inferiority randomized controlled trial (n = 94), partici…

BACKGROUND: Endometriosis is a common gynecologic condition in which pelvic MRI plays an important role in diagnosis and preoperative assessment. AI-enabled automated uterus segmentation on pelvic MRI could support endometriosis care by ena…

Endometrial dysfunction represents a central pathological factor underlying recurrent implantation failure and infertility. This review provides a comprehensive synthesis of the physiological basis of endometrial function, the pathological …

INTRODUCTION AND AIMS: Fertility preservation refers to the cryopreservation of gametes, embryos, or gonadal tissue before age, disease, or medical treatment affects reproductive capacity. Fertility preservation techniques were originally d…

With the rapid progression of urbanization and the widespread adoption of nocturnal work and lifestyle patterns, artificial light at night (ALAN) has emerged as a significant environmental factor impacting women's health. Current research s…

ObjectiveTo compare the effects of frozen-thawed embryo transfer at different times after hysteroscopic endometrial polyp resection on pregnancy outcomes and to provide evidence for individualized clinical treatment.MethodsThis study was a …

BackgroundDeclining fertility rates are a globally documented problem, affecting even regions that have historically high fertility rates. In the Asia Pacific (APAC) region, most countries and territories are seeing birth rates drop far bel…

PurposeTo determine whether intracytoplasmic sperm injection (ICSI) improves cumulative live birth rates (cLBR) compared with conventional IVF among patients with non-male factor infertility.MethodsThis descriptive retrospective cohort stud…

BACKGROUND: Endometriosis is a complex gynaecological disorder that affects 10%-15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction is implicated in en…

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is systematically com…

Recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) remain major challenges in reproductive medicine. Although immune mechanisms are integral to implantation, clinical translation has been limited by indiscriminate use o…

IntroductionChromosomal abnormalities (CA) are a key genetic contributor to infertility, particularly in regions with high consanguinity. Despite growing utilization of assisted reproductive techniques (ART) in the Gulf region, large-scale …

BackgroundReproductive tract infections (RTIs) including sexually transmitted infections (STIs), endogenous and iatrogenic infections, are a major health concern globally, particularly among young females in developing nations. If untreated…

ObjectiveTo evaluate the association between prophylactic antibiotic regimen (cefazolin alone vs. cefazolin plus metronidazole) and the occurrence of surgical site infections (SSIs), as well as infection severity and management, in patients…