Frontiers in reproductive health

Uterine fibroids are the most common benign smooth muscle neoplasm of the uterine wall and are a major indication for hysterectomy. Although common risk factors include African Ancestry, family history, obesity, and early menarche, exposure…

BACKGROUND: Endometriosis is a complex gynaecological disorder that affects 10%-15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction is implicated in en…

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is systematically com…

Recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) remain major challenges in reproductive medicine. Although immune mechanisms are integral to implantation, clinical translation has been limited by indiscriminate use o…

INTRODUCTION: In 2024, an international consensus statement on non-invasive imaging techniques for the diagnosis of pelvic deep endometriosis was published, recommending transvaginal sonography as the first-line imaging modality because of …

INTRODUCTION: Chromosomal abnormalities (CA) are a key genetic contributor to infertility, particularly in regions with high consanguinity. Despite growing utilization of assisted reproductive techniques (ART) in the Gulf region, large-scal…

BACKGROUND: Intraperitoneal adhesions are a major cause of chronic pelvic pain, infertility, tubal ectopic pregnancy, intestinal obstruction and increased surgical time globally. OBJECTIVE: To determine the prevalence, pattern and factors …

BACKGROUND: Reproductive tract infections (RTIs) including sexually transmitted infections (STIs), endogenous and iatrogenic infections, are a major health concern globally, particularly among young females in developing nations. If untreat…

OBJECTIVE: To evaluate the association between prophylactic antibiotic regimen (cefazolin alone vs. cefazolin plus metronidazole) and the occurrence of surgical site infections (SSIs), as well as infection severity and management, in patien…

INTRODUCTION: Climate change is increasing the frequency and severity of wildfires globally, leading to elevated air pollution and potential human health risks. This study examines whether large-scale wildfires impact indoor air quality wit…

Endometriosis is a chronic inflammatory gynecological condition associated with severe dysmenorrhea, chronic pelvic pain, deep dyspareunia, cyclic bowel or urinary symptoms and infertility. It is also linked to psychological morbidity, redu…

INTRODUCTION: In this exploratory case-control study, we investigated the potential associations of pregnancy-associated plasma protein-A (PAPP-A), β-human chorionic gonadotrophin (β-HCG), vascular endothelial growth factor (VEGF), and leuk…

BACKGROUND: Hysterectomy is a commonly performed gynecological surgery for conditions such as uterine fibroids, endometriosis, and abnormal uterine bleeding. However, the procedure provides therapeutic benefits, its increasing prevalence at…

BACKGROUND: Adenomyosis can be categorized using various systems based on its extent, location, and severity. Depending on its location within the endometrium adenomyosis can be classified as intrinsic (inner myometrium) or extrinsic (outer…

BACKGROUND: Endometriosis is a heterogeneous gynecological disease manifesting in three distinct phenotypes: superficial peritoneal endometriosis (SUP), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). While Genome-Wid…

BACKGROUND: Polycystic Ovary Syndrome (PCOS), a prevalent metabolic and reproductive disorder, significantly impacts women of reproductive age. The conventional approach offers various symptomatic pharmacological interventions for PCOS, but…

BACKGROUND: Prior studies show that people with larger bodies experience pervasive weight stigma, which is often directly perpetuated by healthcare providers. This pattern has also been observed in women receiving prenatal and postpartum ca…

BACKGROUND: Dysmenorrhea is a cramping pain during menstrual period and the leading cause for recurrent short-term school absenteeism among adolescent girls. However, evidence on the factors associated with the occurrence of dysmenorrhea, s…

Autoimmune and inflammatory rheumatic diseases (RDs) are more prevalent in women and often affect gynecological health. Particularly, heavy menstrual bleeding (HMB) and dysmenorrhea are more common in patients with RD. A link between RDs an…

BACKGROUND: Assisted reproductive technology (ART) is widely used, yet potential effects on androgen-sensitive male genital development remain a concern. Anoscrotal distance (ASD), a validated marker of prenatal androgen exposure, may diffe…

OBJECTIVE: To investigate the correlation between vitamin D levels and clinical pregnancy rates in infertile women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) procedures and to assess the utility of vitam…

A 30-year-old woman with a body mass index of 20.6 kg/m² consulted due to two years of primary infertility. The patient had a history of two unsuccessful previous rounds of ovarian stimulation for IVF due to poor ovarian response. A novel o…

BACKGROUND: Although azithromycin has demonstrated potential therapeutic efficacy in the treatment of chronic endometritis (CE), comprehensive studies on the optimal timing of administration are lacking. Our study aims to evaluate the impac…

BACKGROUND: Endometriosis is a benign and chronic gynecological estrogen-dependent disease. Research has shown that endometriosis can affect various dimensions of women's lives. It is recommended that programs be developed to improve the qu…

INTRODUCTION: Frozen embryo transfer (FET) is a standard procedure that improves live birth rates and reduces ovarian hyperstimulation risks. Optimizing luteal phase support with hormone replacement therapy (HRT), particularly by progestero…