Spontaneous Endometriosis in a Mandrill (Mandrillus sphinx)

S. Nakamura, Shizuo Nakamura, Nakamura S, K Ochiai, Kuniyasu Ochiai, Ochiai K, A Ochi, Ochi A, Akira Ochi, M Ito, Ito M, Masayuki Itô, Kamiya T, T Kamiya, Toshiyuki Kamiya, H Yamamoto, Haruko Yamamoto, Yamamoto H
Journal of comparative pathology · 2012 · vol. 147(2-3) , pp. 386–390 · doi:10.1016/j.jcpa.2012.01.004 · PMID:22520805 · W2093339341
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This report describes the first documented case of spontaneous endometriosis, a common gynecological condition, in a male mandrill (Mandrillus sphinx).

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Abstract

A 25-year-old female mandrill (Mandrillus sphinx) died after exhibiting weakness and recumbency with serosanguineous ascites. Gross findings included haemoperitoneum and multifocal to diffuse serosal thickening with petechiae and ecchymoses throughout the peritoneum. The uterus was covered entirely with large blood clots and was adherent to the ovaries and pelvic wall. Microscopical and immunohistochemical examination revealed extra- and intra-uterine growth of ectopic endometrial tissue with marked fibrosis. The ectopic endometrial tissues predominantly consisted of stromal cells expressing CD10 and progesterone receptor and variably-sized glands lined by the epithelium with occasional slight expression of oestrogen receptor α. A diagnosis of endometriosis was made. This is the first report of naturally occurring endometriosis in a mandrill.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Mandrillus Monkey Diseases Animals Endometriosis Endometriosis Endometriosis Fatal Outcome Female Monkey Diseases Monkey Diseases Neprilysin Neprilysin Receptors, Progesterone Receptors, Progesterone Stromal Cells Stromal Cells Stromal Cells

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