Effects of Danazol on the epididymal function in male langurs (Presbytis entellus entellus Dufresne)

Ch.L. GUPTA, C L Gupta, V P Dixit
Andrologia · 2009 · vol. 13(4) , pp. 314–321 · doi:10.1111/j.1439-0272.1981.tb00053.x · PMID:7283185 · W2060138049
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Danazol treatment in male langurs resulted in sperm-devoid epididymides and altered biochemical parameters, with effects reversing after cessation, suggesting an inhibitory action on steroidogenesis.

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Abstract

Danazol (28 mg/kg body weight) was administered intramuscularly (i.m.) to intact langurs for a period of 48 days. Epididymides weight showed no significant change but tubular lumina were devoid of spermatozoa. These effects were reversible after 180 days of recovery period. Possible antiandrogenic action of the drug was evaluated by administering Danazol in conjunction with testosterone propionate (TP) (0.7 mg/kg body weight) to castrated langurs. Biochemical estimations for total protein and sialic acid contents showed a significant fall in all the treated groups. Whereas, alkaline phosphatase activity was increased in Danazol treated langurs and a decrease was noticed in castrates, which returned to near normal level after recovery period in intact and TP treatment in castrates. In conclusion, the present findings demonstrate that Danazol effectively suppressed the action of testosterone propionate in castrates. The inhibitory effects of Danazol on steroidogenesis in intact langurs might be due to biochemical interaction at subcellular system.

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MeSH descriptors

Cercopithecidae Danazol Epididymis Pregnadienes Alkaline Phosphatase Alkaline Phosphatase Animals Castration Cercopithecidae Danazol Epididymis Epididymis Male Organ Size Organ Size Pregnadienes Testosterone Testosterone

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References (24)

SciLite annotations

chemicals 10
danazol danazol danazol testosterone propionate sialic acid danazol danazol testosterone propionate danazol
organisms 6
trachypithecus francoisi semnopithecus entellus trachypithecus francoisi trachypithecus francoisi trachypithecus francoisi trachypithecus francoisi

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