Chronic pelvic pain syndrome: Highlighting medicinal plants toward biomolecules discovery for upcoming drugs formulation

Bahare Salehi, Monica Butnariu, Mihaela Corneanu, Ioan Sarac, Ioan Sărac, Sanja Vlaisavljević, Dusanka Kitic, Dušanka Kitić, Amirhossein Rahavian, Amir Reza Abedi, Amirreza Abedi, Morteza F Karkan, Morteza Fallah Karkan, Indra D. Bhatt, Arvind Jantwal, Javad Sharifi‐Rad, Célia F. Rodrigues, Miquel Martorell, Natália Martins
Phytotherapy research : PTR · 2019 · vol. 34(4) , pp. 769–787 · doi:10.1002/ptr.6576 · PMID:31799719 · W2994353774
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This review surveys biomedical data on medicinal plants and their secondary metabolites for managing chronic pelvic pain syndrome (CPPS), aiming to discover biomolecules for future drug formulations.

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Abstract

Chronic pelvic pain syndrome (CPPS) can be triggered by a various types of gynecological, gastrointestinal, urological, and musculoskeletal disorders. Recently, the role of the central nervous system has proven to be an integral part on the development of any chronic pain syndrome, including CPPS. However, owing to the complex and heterogeneous etiology and pathophysiology of CPPS, the establishment of effective therapeutic interventions remains challenging for both physicians and patients. Nonetheless, recent studies have pointed that medicinal plants and their secondary metabolites can be effectively used in CPPS therapy, besides contributing to restore the patients' quality of life and potentiate the conventional CPPS management. In this sense, this review aims to provide a careful overview on the biomedical data for the use of medicinal plants use and their secondary metabolites on CPPS management.

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Condition tags

chronic_pelvic_pain

MeSH descriptors

Chronic Pain Drug Compounding Drug Compounding Drug Compounding Drug Discovery Drug Discovery Drug Discovery Pelvic Pain Phytochemicals Plants, Medicinal Plants, Medicinal Plants, Medicinal Chronic Disease Chronic Pain Female Humans Male Pelvic Inflammatory Disease Pelvic Inflammatory Disease Pelvic Pain

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License: CC0 · commercial use OK