Hubungan Obesitas Menurut Pola Distribusi Lemak Tubuh dengan Kejadian Endometriosis

Hubungan Obesitas Menurut Pola Distribusi Lemak Tubuh dengan Kejadian Endometriosis DOI: https://doi.org/10.20961/plexus.v1i4.295Keywords: endometriosis; , adipositas; , obesitas, pola distribusi lemakAbstract Latar belakang: Endometriosis merupakan salah satu gangguan ginekologis berkaitan hormon estrogen dan berkembang melalui mekanisme peradangan. Pola distribusi jaringan lemak memiliki kaitan dengan hormon estrogen dan peningkatan masa jaringan lemak dapat mempengaruhi sistem pertahanan tubuh. Penelitian ini bermaksud untuk mempelajari hubungan antara keberadaan jaringan lemak berlebih pada regio tertentu dengan endometriosis. Metode Penelitian: Studi observasi potong lintang dilakukan pada pasien tindakan pembedahan pada poli obstetri dan ginekologi RSUD Dr. Moewardi dan RS UNS. Sebanyak 87 pasien dibagi menjadi kelompok normal, obesitas sentral, dan obesitas perifer berdasarkan hasil pengukuran indikator antropometri serta dilakukan pendataan konfirmasi endometriosis menurut hasil lab patologi anatomi. Data kemudian dianalisis dengan menggunakan uji kai kuadrat Pearson. Hasil Peneltian: Subjek pada kelompok endometriosis berusia lebih muda dibandingkan kelompok non endometriosis (p 0,05). Dismenorrhea dibuktikan berhubungan dengan endometriosis (p > 0,05), namun hubungan tidak ditemukan antara endometriosis dengan infertilitas. Analisis statistik tidak menunjukkan adanya hubungan yang signifikan secara statistik antara obesitas menurut pola distribusi lemak tubuh dengan kejadian endometriosis. Simpulan Penelitian: Obesitas menurut pola distribusi lemak tubuh tidak berhubungan dengan kejadian endometriosis. Kata Kunci: endometriosis; adipositas; obesitas; pola distribusi lemak References Amato, M., Pizzolanti, G., Torregrossa, V., Misiano, G., Milano, S., & Giordano, C. (2014). Visceral Adiposity Index (VAI) Is Predictive of an Altered Adipokine Profile in Patients with Type 2 Diabetes. PLoS ONE, 9(3). doi:doi:10.1371/journal.pone.0091969 Backonja, U., Buck Louis, G., & Lauver, D. (2016). Overall Adiposity, Adipose Tissue Distribution, and Endometriosis: A Systematic Review. 65(2), 151-66. doi:10.1097/NNR.0000000000000146 Bourgioti, C., Preza, O., Panourgias, P., Chatoupis, K., Antoniou, A., Nikolaidou, M., & Moulopoulos, L. (2017). MR imaging of endometriosis: Spectrum of disease. Diagnostic and Interventional Imaging, 98(11), 751-767. doi:https://doi.org/10.1016/j.diii.2017.05.009 Bracht, J., Vieira-Potter, V., Santos, R., Öz, O., Palmer, B., & Clegg, D. (2019). The role of estrogens in the adipose tissue milieu. Annals of the New York Academy of Sciences, 1-17. doi:10.1111/nyas.14281 Czernichow, S., Kengne, A. P., Huxley, R. R., Batty, G. D., de Galan, B., Grobbee, D., . . . Group, A. C. (2011). Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 18(2), 312-319. doi:https://doi.org/10.1097/HJR.0b013e32833c1aa3 Czernichow, S., Kengne, A., Huxley, R. R., Batty, G., de Galan, B., Grobbee, D., . . . Chalmers, J. (2011). Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. 18(2), 312-319. Delbandi, A., Mahmoudi, M., Shervin, A., Heidari, S., Kolahdouz-Mohammadi, R., & Zarnani, A. (2020). Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls. BMC Women's Health, 20(3). doi:https://doi.org/10.1186/s12905-019-0865-4 Eaton, S., & Sethi, J. (2019). Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism. Biology, 8(8). doi::10.3390/biology8010008 Giannella, L., Marconi, C., Di Giuseppe, J., Delli Carpini, G., Fichera, M., Grelloni, C., . . . Ciavattini, A. (2021). Malignant Transformation of Postmenopausal Endometriosis: A Systematic Review of the Literature. Cancers (Basel), 13(16). doi:10.3390/cancers13164026 Gregor, M., & Hotamisligil, G. (2011). Inflammatory Mechanisms in Obesity. Annual Review of Immunology, 29(1), 415-445. doi:10.1146/annurev-immunol-031210-101322 Haas, D., Chvatal, R., Reichert, B., Renner, S., Shebl, O., Binder, H., . . . Oppelt, P. (2012). Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis. Arch Gynecol Obstet, 2012 Sep;286(3), 667-70. doi:10.1007/s00404-012-2361-z Hanina, M., Fauzi, A., & Krisna, R. (2018). Hubungan Obesitas Dengan Kejadian Endometriosis di RSUP Dr. Mohammad Hoesin Palembang Periode 1 Januari 2015-31 Desember 2016. Majalah Kedokteran Sriwijaya, 4, 107-113. Dipetik Maret 25, 2020, dari https://ejournal.unsri.ac.id/index.php/mks/article/download/8570/4560 Herrington, J., Bruner-Tan, K., Lucas, J., & Osteen, K. (2011). Immune interactions in endometriosis. Expert Review of Clinical Immunology, 7(8), 611-626. doi:10.1586/eci.11.53 Hetemäki, N., Mikkola, T., Tikkanen, M., Wang, F., Hämäläinen, E., Turpeinen, U., . . . Savolainen-Peltonen, H. (2020). Adipose tissue estrogen production and metabolism in premenopausal women. Journal of Steroid Biochemistry and Molecular Biology, 209(105849). doi:https://doi.org/10.1016/j.jsbmb.2021.105849 Holdsworth-Carson, S., Dior, U., Colgrave, E., Healey, M., Montgomery, G., Rogers, P., & Girling, J. (2018). The association of body mass index with endometriosis and disease severity in women with pain. Journal of Endometriosis and Pelvic Pain Disorder, 10(2), 79-87. doi:10.1177/2284026518773939 Iacobini, C., Pugliese, G., Fantauzzi, C. B., Federici, M., & Menini, S. (2018). Metabolically healthy versus metabolically unhealthy obesity. Metabolism Clinical and Experimental. doi:10.1016/j.metabol.2018.11.009 Kim, M. S., Choi, Y. J., & Lee, Y. H. (2019). Visceral fat measured by computed tomography and the risk of breast cancer. Transl Cancer Res, 8(5), 1939-1949. doi:10.21037/tcr.2019.09.16 Liu, F., He, J., Wang, H., Zhu, D., & Bi, Y. (2020). Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction. OBES SURG, 30, 5086–5100. doi:10.1007/s11695-020-04983-6 Meza-Perez, S., & Randall, T. (2017). Immunological Functions of the Omentum. Immunology, 38(7), 526-536. doi:https://doi.org/10.1016/j.it.2017.03.002 Mori, T., Ito, F., Koshiba, A., Kataoka, H., Takaoka, O., Okimura, H., . . . Kitawaki, J. (2019). Local estrogen formation and its regulation in endometriosis. Reproductive Medicine and Biology, 18(4), 305-311. doi:10.1002/rmb2.12285 Onstad, M., Schmandt, R., & Lu, K. (2016). Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment. Journal of Clinical Oncology, 34(35), 4225-4230. doi:10.1200/JCO.2016.69.4638 Sedlacek, A., Gerber, S., Randall, T., van Rooijen, N., Frelinger, J., & Lor, E. (2013). Generation of a Dual-Functioning Antitumor Immune Response in the Peritoneal Cavity. The American Journal of Pathology, 183(4). doi:http://dx.doi.org/10.1016/j.ajpath.2013.06.030 Shafrir, A., Farland, L., Shah, D., Harris, H., Kvaskoff, M., Zondervan, K., & Missmer, S. (2018). Risk for and consequences of endometriosis: A critical epidemiologic review. Best Practice & Research Clinical Obstetrics and Gynaecology. doi:10.1016/j.bpobgyn.2018.06.001 Tang, Y., Zhao, M., Lin, L., Gao, Y., Chen, G., Chen, S., & Chen, Q. (2020). Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China? BMJ Open, 10(10:e037095). doi:10.1136/bmjopen-2020-037095 Tsatsoulis, A., & Paschou, S. (2020). Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences. Current Obesity Reports, 9(2), 109-120. doi:10.1007/s13679-020-00375-0 Wise, M. R., Jordan, V., Lagas, A., Showell, M., Wong, N., Lensen, S., & Farquhar, C. M. (2016). Obesity and endometrial hyperplasia and cancer in premenopausal women: A systematic review. Am J Obstet Gynecol, 214(6), 689.e1-689.e17. doi:10.1016/j.ajog.2016.01.175 Downloads Published Issue Section License Copyright (c) 2022 Amira Masiah Syahvira, Eriana Melinawati, Yusuf Ari Mashuri This work is licensed under a Creative Commons Attribution 4.0 International License. Copyright @2022. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).