Association of G1057D variant of insulin receptor substrate-2 with endometriosis

Filiz Cayan, Filiz Çayan, Cayan F, Devrim Ertunç, Ertunç D, Aras-Ateş N, Nurcan Aras-Ateş, Lokman Ayaz, Akbay E, Esen Akbay, Karakaş S, Sevim Karakaş, Coban O, Ozgür Coban, Özgür Çoban, Saffet Dilek, Saffet Dılek, Dilek S
Fertility and sterility · 2009 · vol. 94(5) , pp. 1622–1626 · doi:10.1016/j.fertnstert.2009.09.023 · PMID:19878940 · W2017691022
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This paper investigated the G1057D variant of insulin receptor substrate-2 and found an association with endometriosis.

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Abstract

OBJECTIVE: To investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis. DESIGN: Case-control study. SETTING: Gynecology clinics in university hospital. PATIENT(S): Women with (n = 135) or without (n = 135) endometriosis. Afterward, the women with endometriosis were divided into two groups according to the stage: group 1 included 63 women in stages I-II, and group 2 included 72 women in stages III-IV. INTERVENTION(S): Genotyping by polymerase chain reaction-based restriction fragment-length polymorphism method. MAIN OUTCOME MEASURE(S): Genotype distribution of the G1057D polymorphism in the IRS2 gene. RESULT(S): The genotype distribution of the IRS2 G1057D polymorphism in the endometriosis group was significantly different from that of the control group (GG/GD/DD rates were 43.0%/39.3%/17.7% and 55.6%/36.3%/8.1% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis also revealed a positive association between the IRS2 DD genotype expression and stage III-IV endometriosis patients in the population studied. CONCLUSION(S): These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Insulin Receptor Substrate Proteins Polymorphism, Genetic Uterine Diseases Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype Humans Humans Insulin Receptor Substrate Proteins

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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