Association of G1057D variant of insulin receptor substrate-2 with endometriosis

Filiz Cayan, Filiz Çayan, Cayan F, Devrim Ertunç, Ertunç D, Aras-Ateş N, Nurcan Aras-Ateş, Lokman Ayaz, Akbay E, Esen Akbay, Karakaş S, Sevim Karakaş, Coban O, Ozgür Coban, Özgür Çoban, Saffet Dilek, Saffet Dılek, Dilek S
Fertility and sterility · 2009 · vol. 94(5) , pp. 1622–1626 · doi:10.1016/j.fertnstert.2009.09.023 · PMID:19878940 · W2017691022
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This paper investigated the G1057D variant of insulin receptor substrate-2 and found an association with endometriosis.

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Abstract

ObjectiveTo investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis.DesignCase-control study.SettingGynecology clinics in university hospital.Patient(s)Women with (n = 135) or without (n = 135) endometriosis. Afterward, the women with endometriosis were divided into two groups according to the stage: group 1 included 63 women in stages I-II, and group 2 included 72 women in stages III-IV.Intervention(s)Genotyping by polymerase chain reaction-based restriction fragment-length polymorphism method.Main outcome measure(s)Genotype distribution of the G1057D polymorphism in the IRS2 gene.Result(s)The genotype distribution of the IRS2 G1057D polymorphism in the endometriosis group was significantly different from that of the control group (GG/GD/DD rates were 43.0%/39.3%/17.7% and 55.6%/36.3%/8.1% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis also revealed a positive association between the IRS2 DD genotype expression and stage III-IV endometriosis patients in the population studied.Conclusion(s)These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Insulin Receptor Substrate Proteins Polymorphism, Genetic Uterine Diseases Adult Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Humans Insulin Receptor Substrate Proteins Middle Aged Polymorphism, Genetic Risk Factors Severity of Illness Index Uterine Diseases

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