CA 125 levels in endometriosis patients before, during and after treatment with Danazol or LHRH agonists

P Acien, Acien P, Pedro Acién, Shaw RW, Robert W. Shaw, R W Shaw, L Irvine, L. M. Irvine, Irvine L, Burford G, G. D. Burford, G Burford, Gardner R, R Gardner, Rosemary Gardner
European journal of obstetrics, gynecology, and reproductive biology · 1989 · vol. 32(3) , pp. 241–246 · doi:10.1016/0028-2243(89)90042-7 · PMID:2676640 · W1973394935
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This paper investigated changes in CA 125 levels in endometriosis patients receiving Danazol or LHRH agonist treatments and analyzed the correlation between these changes and treatment outcomes.

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Abstract

The levels of CA 125 in the serum of 54 patients with endometriosis were measured before, during and after treatment with Danazol or LHRH analogues. Patients with minimal and mild endometriosis had mean pre-treatment values significantly higher than control subjects in the luteal phase of the cycle or postmenopausal women (p less than 0.05), but levels were within the overall control range. In contrast, 78.6% of patients with moderate or severe endometriosis had levels in excess of 30 mu/ml and the mean values for these groups were significantly elevated (p less than 0.005). Levels of CA 125 fell, to those found in normal controls, during treatment, but rose again following cessation of treatment. Six of 12 subjects whose follow-up values of CA 125 exceeded 30 U/ml had a proven recurrence of endometriosis, whilst only 2 of 31 patients with values less than 30 U/ml had laparoscopically proven recurrence.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Danazol Endometriosis Gonadotropin-Releasing Hormone Pregnadienes Adult Antigens, Tumor-Associated, Carbohydrate Danazol Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Pregnadienes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (10)

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