CA 125 Antigen Is an Effective Diagnostic for External Endometriosis

Takahashi K, K. Takahashi, Kentaro Takahashi, Y Yamane, Yamane Y, Yoshio Yamane, Satoshi Kijima, S Kijima, Kijima S, Kazuo Yoshino, K. Yoshino, Yoshino K, Toshihiko Shibukawa, T Shibukawa, Shibukawa T, M Kitao, Kitao M, Manabu Kitao
Gynecologic and obstetric investigation · 2010 · vol. 23(4) , pp. 257–260 · doi:10.1159/000298869 · PMID:3475234 · W1977540391
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Serum CA 125 levels were elevated in external endometriosis patients, with higher levels and positive rates correlating with disease stage and decreasing after treatment.

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Abstract

We measured serum levels of CA 125 in 26 patients with external endometriosis, using CA 125 RIA Kits. The normal range was instituted below 39 U/ml. The mean CA 125 level (+/- SD) was 55.1 +/- 24.9 U/ml in patients with external endometriosis, the positive rate being 71.4%. Considering the clinical stage of external endometriosis, the mean CA 125 level and positive rate increased to 64.5 +/- 23.2 U/ml and 93.3%, respectively. The CA 125 levels in these patients gradually decreased after surgery and/or Danazol treatment and the levels were below 39 U/ml within four weeks. Thus, progressive external endometriosis can be accurately diagnosed by determining the serum levels of CA 125, and appropriate clinical treatment designed.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Neoplasm Danazol Endometriosis Pregnadienes Adult Antigens, Neoplasm Antigens, Tumor-Associated, Carbohydrate Danazol Endometriosis Endometriosis Female Humans Pregnadienes Reference Values

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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